2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

Base Information

Chemical Name:2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide
CAS No.:1415834-78-4
Molecular Formula:C₂₁H₁₇F₃N₂O₂
Molecular Weight:386.373
Hs Code.:

Synonyms:2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

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Chemical Property of 2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

Chemical Property:

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Technology Process of 2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

There total 6 articles about 2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₃FN₂O

: 85068-28-6
2,6-difluorophenylacetic acid

: 1415834-78-4
2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2013.01.014

Reference yield:

: 1570-45-2
isonicotinic acid ethylester

: 1415834-78-4
2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 °C / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C / Enzymatic reaction

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 0 - 20 °C

4.1: p-toluenesulfonyl chloride / dichloromethane / 1.33 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 48 h / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C

With dmap; lithium aluminium tetrahydride; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.01.014

Reference yield:

: C₁₃H₁₂FNO₂

: 1415834-78-4
2-(2,6-difluorophenyl)-N-[4-(4-fluorobenzyloxymethyl)pyridin-2-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonyl chloride / dichloromethane / 1.33 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 48 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 24 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2013.01.014