(S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester
CAS No.:198904-77-7
Molecular Formula:C₁₃H₂₅N₃O₅
Molecular Weight:303.359
Hs Code.:

Synonyms:(S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

Suppliers and Price of (S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl2-(2-((methoxycarbonyl)amino)-3,3-dimethylbutanoyl)hydrazinecarboxylate 97%
5g
$ 982.00

Crysdot
(S)-tert-Butyl2-(2-((methoxycarbonyl)amino)-3,3-dimethylbutanoyl)hydrazinecarboxylate 97%
1g
$ 327.00

Total 1 raw suppliers

Chemical Property of (S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: (S)-tert-Butyl2-(2-((methoxycarbonyl)amino)-3,3-dimethylbutanoyl)hydrazinecarboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

There total 2 articles about (S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 162537-11-3
(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid

: 198904-77-7
(S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 18.75h;

Reference yield:

: 20859-02-3
L-tert-Leucine

: 198904-77-7
(S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 2N aq. NaOH / dioxane / 18 h / 60 °C

2: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / 1.) EtOAc, 30 min, 2.) EtOAc, 16 h

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane;
DOI:10.1021/jm970873c

Reference yield:

: 198904-77-7
(S)-N'-(2-methoxycarbonylamino-3,3-dimethyl-butyryl)-hydrazinecarboxylic acid tert-butyl ester

: 198904-31-3,1292296-09-3
atazanavir

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / tetrahydrofuran / 2 h / 20 °C

2.1: triethylamine / ethanol / 1 h / 20 °C / Inert atmosphere

2.2: 4 h / Inert atmosphere; Reflux

3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 12 h / 20 °C / 760.05 Torr

4.1: sodium iodide / acetonitrile / 0.25 h / 20 °C

4.2: 0.25 h / 20 °C

5.1: lithium tri-t-butoxyaluminum hydride / diethyl ether / 4 h / 0 °C

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium iodide; In tetrahydrofuran; diethyl ether; ethanol; acetonitrile;
DOI:10.1021/op7001563