methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate

Base Information

• Chemical Name: methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate
• CAS No.: 861631-61-0
• Molecular Formula: C₂₀H₁₆N₂O₅
• Molecular Weight: 364.357
• Mol file: 861631-61-0.mol

Synonyms:methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate

Chemical Property of methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate

There total 3 articles about methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-[2-hydroxy-2-(2-methoxyquinolin-3-yl)ethyl]-4-nitrobenzoate (851777-21-4) → methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate (861631-61-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; In Isopropyl acetate; for 14h;

DOI:10.1016/j.tet.2005.03.142

Reference yield:

methyl 3-methyl-4-nitrobenzoate (24078-21-5) → methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate (861631-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DBU / dimethylsulfoxide / 3 h

2: 87 percent / trifluoroacetic anhydride; DBU / isopropyl acetate / 14 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; In Isopropyl acetate; dimethyl sulfoxide;

DOI:10.1016/j.tet.2005.03.142

Reference yield:

2-methoxy-3-quinolinecarboxyaldehyde (139549-06-7) → methyl 3-[(E)-2-(2-methoxyquinolin-3-yl)vinyl]-4-nitrobenzoate (861631-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DBU / dimethylsulfoxide / 3 h

2: 87 percent / trifluoroacetic anhydride; DBU / isopropyl acetate / 14 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; In Isopropyl acetate; dimethyl sulfoxide;

DOI:10.1016/j.tet.2005.03.142

upstream raw materials:

methyl 3-[2-hydroxy-2-(2-methoxyquinolin-3-yl)ethyl]-4-nitrobenzoate

methyl 3-methyl-4-nitrobenzoate

2-methoxy-3-quinolinecarboxyaldehyde