24078-21-5

Usage

InChI:InChI=1/C9H9NO4/c1-6-5-7(9(11)14-2)3-4-8(6)10(12)13/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 74-88-4 methyl iodide 
• 80866-75-7 3-methyl-4-nitrobenzyl alcohol 
• 865-33-8 potassium methanolate 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 99-04-7 m-Toluic acid 
• 89-87-2 2,4-dimethylnitrobenzene 
• 77-78-1 dimethyl sulfate 
• 619-50-1 4-nitrobenzoic acid methyl ester 

Downstream Products

• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 72198-83-5 3-methyl-4-nitrobenzoylhydrazine 
• 1011-65-0 5-methoxycarbonylindole 
• 111168-49-1 methyl 1-hydroxy-5-indolecarboxylate 
• 108763-41-3 methyl (E)-3-(2-(dimethylamino)vinyl)-4-nitrobenzoate 
• 851777-28-1 methyl 2-(6-bromopyridin-2-yl)-2,3-dihydro-1-benzofuran-5-carboxylate 
• 851777-29-2 methyl 2-(2-bromopyridin-3-yl)-2,3-dihydro-1-benzofuran-5-carboxylate 
• 851777-21-4 methyl 3-[2-hydroxy-2-(2-methoxyquinolin-3-yl)ethyl]-4-nitrobenzoate 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 81461-95-2 3-Bromomethyl-4-(2-oxo-azetidin-1-yl)-benzoic acid 
• 81461-90-7 4-(2-Oxo-azetidin-1-yl)-3-phenoxymethyl-benzoic acid 
• 81461-97-4 4-(2-Oxo-azetidin-1-yl)-3-phenoxymethyl-benzoic acid methyl ester 
• 88089-56-9 3-Methyl-4-(2-oxo-azetidin-1-yl)-benzoic acid 
• 88072-21-3 3-Methyl-4-(2-oxo-azetidin-1-yl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Novel preparation method of antihypertensive drug telmisartan intermediate

The invention relates to an electric reduction preparation method of aminobenzoic acid represented by formula I and ester thereof. The preparation reaction of the method is shown in the description; and in the reaction formula, R is selected from hydrogen, a methyl group, an ethyl group, a benzyl group, a C3 or C4 straight-chain alkyl or branched-chain alkyl group, -NO2 is selected from 4-NO2 or 5-NO2, and Y is selected from H or 4-NHCOC3H7-n. The electroreduction preparation method of aminobenzoic acid and ester I thereof is characterized in that in a separated electrolytic cell, an acidic solution of nthe itrobenzoic acid and ester III thereof is taken as a catholyte; the voltage of a cathode working electrode relative to a reference electrode is 1.00-2.50 V; and an anolyte is an acidicsolution, the current density is 25.0-250.0 mA/cm, and the electrolysis temperature is 15-90 DEG C.

O-nitrophenyl ethanol derivative as well as preparation method and application thereof

The invention discloses an o-nitrophenethyl alcohol derivative and a preparation method and application thereof, the structural formula of the o-nitrophenethyl alcohol derivative is shown in the specification, and R is C1-C18 alkyl. The invention provides

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

Aromatic acyl hydrazone derivative and application thereof as NA inhibitor

The invention relates to an aromatic acyl hydrazone derivative as shown in a structural formula I, pharmaceutically acceptable salt and a pharmaceutical composition thereof, and application of the aromatic acyl hydrazone derivative and the pharmaceutically acceptable salt and the pharmaceutical composition in preparation of an influenza virus neuraminidase inhibitor, wherein R is one of trifluoromethyl, nitryl, 3-methyl-4-nitryl, 3-hydroxyl-4-nitryl, 3-nitryl-4-hydroxyl, hydroxyl, dihydroxyl, dinitryl, 3-methoxy-4-hydroxyl or trihydroxyl; Y is selected from hydroxyl, dihydroxyl, 2-hydroxyl-3-methoxy, 2-hydroxyl-4-methoxy,2-hydroxyl-5-methoxy,2-hydroxyl-6-methoxy,3-hydroxyl-2-methoxy,3-hydroxyl-4-methoxy,3-hydroxyl-5-methoxy,3-hydroxyl-6-methoxy,4-hydroxyl-2-methoxy,4-hydroxyl-3-methoxy,4-hydroxyl-3,5-dimethoxy, trihydroxyl, 4-hydroxyl-3-ethoxy, or 4-hydroxyl-3,5-dimethoxy; w is selected from CH or N; and z is selected from CH or N.

Antifungal activity of cinnamic acid and benzoic acid esters against Candida albicans strains

Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure–Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C. albicans strains, presenting the same MIC values (MIC?=?128?μg/mL), followed by methyl biphenyl-2-carboxylate (21) (MIC?=?128, 128 and 256?μg/mL for C. albicans LM-106, LM-23, and ATCC-76645, respectively). Our results suggest that certain molecular characteristics are important for the antifungal action.

Conversion of alcohols to alkyl esters and carboxylic acids using heterogeneous palladium-based catalysts

Disclosed are methods for synthesizing an ester or a carboxylic acid from an organic alcohol. To form the ester one reacts, in the presence of oxygen gas, the alcohol with methanol or ethanol. This reaction occurs in the presence of a catalyst comprising palladium and a co-catalyst comprising bismuth, tellurium, lead, cerium, titanium, zinc and/or niobium (most preferably at least bismuth and tellurium). Alternatively that catalyst can be used to generate an acid from that alcohol, when water is also added to the reaction mix.

C1-Phostphonate Analogue of UDP-GlcNAc for Inhibition of O-GlcNAc Transferase

A novel C1-phosphate analogue of uridine-5′-diphosphate (UDP)-GlcNAc as an effective OGT (O-linked N-acetylglucosamine (O-GlcNAc) transferase) inhibitor, and a preparation method for the same provides a compound having an OGT inhibitory effect that can be

Preparation method of highly selective 3-methyl-2-nitrobenzoic acid

The invention discloses a preparation method of 3-methyl-2-nitrobenzoic acid. 3-methylbenzoic acid alkyl ester is used as raw material in nitrification, two-grade selectivity and high yield are realized, and the amount of waste acid was reduced. In nitrification product, only 3-methyl 2-nitrobenzoic acid alkyl ester and 3-methyl-4-nitrobenzoic acid alkyl ester are hydrolyzed after separation to obtain 3-methyl 2-Nitrobenzoic acid and 3-methyl-4-nitrobenzoic acid. The process is simple, and suitable for industrial production.

Synthesis of a benzene-containing C1-phosphonate analogue of UDP-GlcNAc for the inhibition of O-GlcNAc transferase

I report here the design, synthesis, and biological evaluation of a new C1-phosphonate analogue of UDP-GlcNAc as a potential inhibitor of OGT, an enzyme responsible for O-GlcNAc modification. The analogue was designed to mimic the transition state of the

Synthesis method for 3-formyl-4-methyl nitrobenzoate

The invention relates to a synthesis method for a compound, in particular to a synthesis method for 3-formyl-4-methyl nitrobenzoate.According to synthesis method, a simple and cheap preparation method for 3-formyl-4-methyl nitrobenzoate is supplied, the reaction conditions in the preparation process are mild, and the yield is high.