24078-21-5

Basic information

• Product Name: Methyl 3-methyl-4-nitrobenzoate
• Synonyms: Methyl 3-Methyl-4-nitrobenzoate , 98.0%(GC);3-METHYL-4-NITROBENZOIC ACID METHYL ESTER;4-NITRO-M-TOLUIC ACID METHYL ESTER;BENZOIC ACID, 3-METHYL-4-NITRO-METHYL ESTER;BUTTPARK 62\04-20;METHYL 3-METHYL-4-NITROBENZENECARBOXYLATE;METHYL 3-METHYL-4-NITROBENZOATE;3-methyl-4-nitro benzoate
• CAS NO: 24078-21-5
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17
• EINECS: 230-886-6
• Product Categories: FINE Chemical & INTERMEDIATES;blocks;Carboxes;NitroCompounds;Aromatic Esters;Benzoic acid;Esters;Phenyls & Phenyl-Het;pharmaceutical intermediates
• Mol File: 24078-21-5.mol
• Article Data: 37

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 318.5 °C at 760 mmHg
• Flash Point: 150.6 °C
• Appearance: White to yellowish cystal powder
• Density: 1.255 g/cm³
• Vapor Pressure: 0.00036mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 3-methyl-4-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-methyl-4-nitrobenzoate(24078-21-5)
• EPA Substance Registry System: Methyl 3-methyl-4-nitrobenzoate(24078-21-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 24/25
• Hazardous Substances Data: 24078-21-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9NO4/c1-6-5-7(9(11)14-2)3-4-8(6)10(12)13/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 74-88-4 methyl iodide 
• 89-87-2 2,4-dimethylnitrobenzene 
• 99-04-7 m-Toluic acid 
• 77-78-1 dimethyl sulfate 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 80866-75-7 3-methyl-4-nitrobenzyl alcohol 
• 865-33-8 potassium methanolate 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 

Downstream Products

• 929897-33-6 methyl 3-(1,3-dioxolan-2-yl)-4-nitrobenzoate 
• 929897-34-7 methyl 4-acetamido-3-(1,3-dioxolan-2-yl)benzoate 
• 929897-20-1 methyl 4-[(tert-butoxycarbonyl)amino]-3-formylbenzoate 
• 929897-35-8 methyl 4-(tert-butoxycarbonylamino)-3-(1,3-dioxolan-2-yl)benzoate 
• 929897-59-6 (2R,3aS,4S,9bR)-5-(tert-butoxycarbonyl)-8-methoxycarbonyl-4-(tert-butyldimethylsilyloxy)-2-[(tert-butyldiphenylsilyloxy)methyl]-2,3,3a,4-tetrahydro-9bH-pyrrolo[3,2-c]quinoline 
• 929897-44-9 (2R,3aR,4R,9bR)-1,5-di-(tert-butoxycarbonyl)-8-methoxycarbonyl-2-[(tertbutyldiphenylsilyloxy)methyl]-4-(3-hydroxypropyl)-2,3,3a,4-tetrahydro-9bH-pyrrolo[3,2-c]quinoline 
• 929897-42-7 (2R,3aS,9bR)-1,5-di-(tert-butoxycarbonyl)-8-methoxycarbonyl-4-(tert-butyldimethylsilyloxy)-2-[(tert-butyldiphenylsilyloxy)methyl]-2,3,3a,4-tetrahydro-9bH-pyrrolo[3,2-c]quinoline 
• 929897-45-0 (2R,3aR,4R,9bR)-1,5-di-(tert-butoxycarbonyl)-8-methoxycarbonyl-4-[3-(benzyloxy)propyl]-2-[(tert-butyldiphenylsilyloxy)methyl]-2,3,3a,4-tetrahydro-9bH-pyrrolo[3,2-c]quinoline 
• 148625-35-8 methyl 3-formyl-4-nitrobenzoate 
• 152628-03-0 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid 
• 301533-59-5 methyl 4-(n-butyrylamino)-3-methylbenzoate 
• 152628-00-7 4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid methyl ester 
• 675882-71-0 3-methyl-4-butyrylamino-5-aminobenzoic acid methyl ester 
• 152628-01-8 4-butyrylamino-3-methyl-5-nitro-benzoic acid methyl ester 

Relevant articles and documents

Novel preparation method of antihypertensive drug telmisartan intermediate

The invention relates to an electric reduction preparation method of aminobenzoic acid represented by formula I and ester thereof. The preparation reaction of the method is shown in the description; and in the reaction formula, R is selected from hydrogen, a methyl group, an ethyl group, a benzyl group, a C3 or C4 straight-chain alkyl or branched-chain alkyl group, -NO2 is selected from 4-NO2 or 5-NO2, and Y is selected from H or 4-NHCOC3H7-n. The electroreduction preparation method of aminobenzoic acid and ester I thereof is characterized in that in a separated electrolytic cell, an acidic solution of nthe itrobenzoic acid and ester III thereof is taken as a catholyte; the voltage of a cathode working electrode relative to a reference electrode is 1.00-2.50 V; and an anolyte is an acidicsolution, the current density is 25.0-250.0 mA/cm, and the electrolysis temperature is 15-90 DEG C.

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

Antifungal activity of cinnamic acid and benzoic acid esters against Candida albicans strains

Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure–Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C. albicans strains, presenting the same MIC values (MIC?=?128?μg/mL), followed by methyl biphenyl-2-carboxylate (21) (MIC?=?128, 128 and 256?μg/mL for C. albicans LM-106, LM-23, and ATCC-76645, respectively). Our results suggest that certain molecular characteristics are important for the antifungal action.