2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

Base Information

Chemical Name:2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid
CAS No.:887476-52-0
Molecular Formula:C₁₄H₁₃ClN₂O₄
Molecular Weight:308.721
Hs Code.:

2-[(5-chloro-1-hydroxy-1<i>H</i>-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

Synonyms:2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

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Chemical Property of 2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

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Technology Process of 2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

There total 3 articles about 2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887476-51-9
2-[(5-chloro-1-methoxymethoxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid 9H-fluoren-9-ylmethyl ester

: 887476-52-0
2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / MgBr₂*Et₂O; EtSH / diethyl ether / 4 h / 20 °C

2: Et₂NH / CH₂Cl₂ / 0.67 h

With diethylamine; ethanethiol; magnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200500856

Reference yield:

: 85812-92-6
Boc-L-Phe-OFm

: 887476-52-0
2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: HCl; water / diethyl ether / 1.5 h / 20 °C

2: 0.24 g / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl; 1H-benzotriazol-1-ol hydrate; ethyldiisopropylamine / CH₂Cl₂ / 4 h / 20 °C

3: 88 percent / MgBr₂*Et₂O; EtSH / diethyl ether / 4 h / 20 °C

4: Et₂NH / CH₂Cl₂ / 0.67 h

With hydrogenchloride; water; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; ethanethiol; magnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200500856

Reference yield:

: 9-fluorenemethyl (S)-phenylalaninate hydrochloride

: 887476-52-0
2-[(5-chloro-1-hydroxy-1H-pyrrole-2-carbonyl)-amino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 0.24 g / N-[3-(dimethylamino)propyl]-N'-ethylcarbodiimide*HCl; 1H-benzotriazol-1-ol hydrate; ethyldiisopropylamine / CH₂Cl₂ / 4 h / 20 °C

2: 88 percent / MgBr₂*Et₂O; EtSH / diethyl ether / 4 h / 20 °C

3: Et₂NH / CH₂Cl₂ / 0.67 h

With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; ethanethiol; magnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1002/ejoc.200500856