(4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

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Chemical Name:(4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone
CAS No.:1088497-65-7
Molecular Formula:C₂₃H₃₉N₃O₂
Molecular Weight:389.582
Hs Code.:

Synonyms:(4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

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Chemical Property of (4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

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Technology Process of (4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

There total 7 articles about (4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: piperazin-1-yl-[6-(tetrahydro-pyran-4-yl)-6-aza-spiro[2.5]oct-1-yl]-methanone bis trifluoroacetic acid salt

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1088497-65-7
(4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

Guidance literature:: With acetic acid; In dichloromethane; at 18 - 25 ℃;

Reference yield:

: 147610-84-2
6-benzyl 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate

: 1088497-65-7
(4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide; water / methanol; tetrahydrofuran

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3: 5%-palladium/activated carbon; hydrogen; acetic acid / ethanol / 0.25 h

4: sodium tris(acetoxy)borohydride; acetic acid / ethanol / 18 h / 20 °C / Reflux

5: dichloromethane / 1.5 h / 20 °C

6: acetic acid / dichloromethane / 20 °C

With 5%-palladium/activated carbon; water; hydrogen; sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm4014828

Reference yield:

: 138163-12-9
benzyl 4-methylene-1-piperidinecarboxylate

: 1088497-65-7
(4-cyclohexylpiperazin-1-yl)(6-(tetrahydro-2H-pyran-4-yl)-6-azaspiro[2.5]octan-1-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: copper(l) cyanide / dichloromethane / 100 h / 20 °C

2: lithium hydroxide; water / methanol; tetrahydrofuran

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

4: 5%-palladium/activated carbon; hydrogen; acetic acid / ethanol / 0.25 h

5: sodium tris(acetoxy)borohydride; acetic acid / ethanol / 18 h / 20 °C / Reflux

6: dichloromethane / 1.5 h / 20 °C

7: acetic acid / dichloromethane / 20 °C

With 5%-palladium/activated carbon; water; hydrogen; copper(l) cyanide; sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm4014828