Technology Process of N-boc-2-(2-chloromethylphenyl)-2,3-dihydro-4-pyridone
There total 3 articles about N-boc-2-(2-chloromethylphenyl)-2,3-dihydro-4-pyridone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 4-oxopyridine-1-carboxylate;
With
n-butyllithium; chloro-trimethyl-silane; isopropylmagnesium bromide;
In
tetrahydrofuran; diethyl ether; hexane;
for 0.166667h;
Inert atmosphere;
2-(chloromethyl)iodobenzene;
In
tetrahydrofuran; diethyl ether; hexane;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/jo400936z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tert-butyl alcohol / 12 h / 20 - 50 °C / Inert atmosphere
2.1: chloro-trimethyl-silane; n-butyllithium; isopropylmagnesium bromide / tetrahydrofuran; hexane; diethyl ether / 0.17 h / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
With
n-butyllithium; chloro-trimethyl-silane; isopropylmagnesium bromide; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; tert-butyl alcohol;
DOI:10.1021/jo400936z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tert-butyl alcohol / 12 h / 20 - 50 °C / Inert atmosphere
2.1: chloro-trimethyl-silane; n-butyllithium; isopropylmagnesium bromide / tetrahydrofuran; hexane; diethyl ether / 0.17 h / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
With
n-butyllithium; chloro-trimethyl-silane; isopropylmagnesium bromide; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; tert-butyl alcohol;
DOI:10.1021/jo400936z
