3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

Base Information

Chemical Name:3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide
CAS No.:914299-34-6
Molecular Formula:C₂₅H₃₁ClN₂O₆
Molecular Weight:490.984
Hs Code.:

Synonyms:3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

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Chemical Property of 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

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Technology Process of 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

There total 19 articles about 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

: 3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-4-methylbenzoic acid

: 75-04-7,85404-22-4
ethylamine

: 914299-34-6
3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 64.2%

: 914298-26-3
5-chloro-2,4-bis(methoxymethoxy)benzoic acid

: 75-04-7,85404-22-4
ethylamine

: 914299-34-6
3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 23 ℃; for 12h;
DOI:10.1016/j.bmcl.2008.09.081

Reference yield:

: 914299-28-8
C₁₁H₁₄IN

: 914299-34-6
3-{1-[5-chloro-2,4-bis(methoxymethoxy)benzoyl]pyrrolidin-2-yl}-N-ethyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / dichloromethane / 5 - 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 12 h / 50 °C / 2585.81 Torr

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 12 h / 20 °C

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

5.1: methanol; lithium hydroxide; water / 12 h / 40 °C

5.2: NaOAc-HOAc buffer

6.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; methanol; lithium hydroxide; water; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;