5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Base Information

Chemical Name:5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one
CAS No.:1442451-90-2
Molecular Formula:C₂₇H₂₅ClF₂N₄O₃
Molecular Weight:526.97
Hs Code.:

Synonyms:5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

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Chemical Property of 5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

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Technology Process of 5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

There total 12 articles about 5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1442451-92-4
5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

: 1442452-47-2
1-chloromethyl-2,4-difluoro-3-methyl-benzene

: 1442451-90-2
5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

Reference yield:

: 112857-68-8
2,4-difluoro-3-methylbenzoic acid

: 1442451-90-2
5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / methanol / 3 h / 60 °C / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with acetone-dry ice

3: sodium hydrogencarbonate; thionyl chloride / dichloromethane / 3 h / 60 °C / Cooling with ice

4: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 3 h / 60 °C

With lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1206675-31-1
2,4-difluoro-3-methyl-benzoic acid methyl ester

: 1442451-90-2
5-chloro-6-(2,4-difluoro-3-methyl-benzyloxy)-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with acetone-dry ice

2: sodium hydrogencarbonate; thionyl chloride / dichloromethane / 3 h / 60 °C / Cooling with ice

3: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 3 h / 60 °C

With lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;