5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

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Chemical Name:5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one
CAS No.:1442451-92-4
Molecular Formula:C₁₉H₁₉ClN₄O₃
Molecular Weight:386.838
Hs Code.:

Synonyms:5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

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Chemical Property of 5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

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Technology Process of 5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

There total 8 articles about 5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1442451-99-1
5-chloro-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-6-(4-methoxy-benzyloxy)-2-methyl-3H-pyrimidin-4-one

: 1442451-92-4
5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 773103-89-2
3-acetimidoylamino-4-methyl-benzoic acid methyl ester

: 1442451-92-4
5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methyl-morpholine / dichloromethane / 18 h / 20 °C / Cooling with ice

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 1 h / 60 °C

3: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 60 °C

4: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 3 h / 20 - 30 °C

5: sodium hydroxide / tetrahydrofuran

6: tetrahydrofuran / 18 h / 20 °C / Cooling with ice

7: potassium carbonate / acetonitrile / 18 h / 75 °C

8: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; 18-crown-6 ether; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 773103-91-6
3-[1-(2-methoxycarbonyl-acetylamino)-ethylideneamino]-4-methyl-benzoic acid methyl ester

: 1442451-92-4
5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 1 h / 60 °C

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 2 h / 60 °C

3: N-chloro-succinimide; dichloro-acetic acid / isopropyl alcohol / 3 h / 20 - 30 °C

4: sodium hydroxide / tetrahydrofuran

5: tetrahydrofuran / 18 h / 20 °C / Cooling with ice

6: potassium carbonate / acetonitrile / 18 h / 75 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With dichloro-acetic acid; N-chloro-succinimide; 18-crown-6 ether; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;