5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

Base Information

Chemical Name:5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole
CAS No.:1314595-91-9
Molecular Formula:C₃₀H₃₁NO₆S
Molecular Weight:533.645
Hs Code.:

Synonyms:5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

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Chemical Property of 5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

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Technology Process of 5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

There total 4 articles about 5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1314595-73-7
(2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3-(prop-2-yn-1-yloxy)-3,6-dihydro-2H-pyran

: 1314595-90-8
N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide

: 1314595-91-9
5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; at 50 ℃; for 2h;
DOI:10.1021/ol201532k

Reference yield:

: C₁₅H₂₂O₃Si

: 1314595-91-9
5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 2 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; sodium hydride; diethylamine; In tetrahydrofuran; mineral oil;
DOI:10.1021/ol201532k

Reference yield:

: C₁₈H₂₄O₃Si

: 1314595-91-9
5-methoxy-2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1-tosyl-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 2 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; sodium hydride; diethylamine; In tetrahydrofuran; mineral oil;
DOI:10.1021/ol201532k