4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

Base Information

Chemical Name:4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride
CAS No.:769881-92-7
Molecular Formula:C₄₈H₇₅N₇O₉Si
Molecular Weight:922.251
Hs Code.:

4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

Synonyms:4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

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Chemical Property of 4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

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Technology Process of 4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

There total 12 articles about 4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 108826-73-9
4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

: 769881-92-7
4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; acetic acid; Ambient temperature;

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 769881-92-7
4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / DCC / pyridine

2: H₂ / 10percent Pd-C / propan-2-ol; acetic acid

3: 72 percent / 1.) HOBt, DCC; 2.) DIEA / dimethylformamide / 16 h / 4 °C

4: 76 percent / 3M HCl / ethyl acetate / 0.5 h / Ambient temperature

5: 65 percent / 1.) HOBt, DCC; 2.) DIEA / dimethylformamide / 16 h / 4 °C

6: 72 percent / H₂ / 10percent Pd-C / acetic acid; H₂O; various solvent(s) / Ambient temperature

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 3338-34-9
Z-Lys(-Boc)-Osu

: 769881-92-7
4-(D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanylamino)butanoic acid 2-trimethylsilylethyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / NEt₃ / acetonitrile / 6 h / 20 °C

2: H₂ / 10percent Pd-C / propan-2-ol; acetic acid

3: 61 percent / 1.) HOBt, DCC; 2.) Et₃N / dimethylformamide / 16 h / 4 °C

4: 93 percent / Et₄NF / dimethylformamide / 0.5 h / 30 °C

5: 65 percent / 1.) HOBt, DCC; 2.) DIEA / dimethylformamide / 16 h / 4 °C

6: 72 percent / H₂ / 10percent Pd-C / acetic acid; H₂O; various solvent(s) / Ambient temperature

With hydrogen; tetraethylammonium fluoride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;