4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

Base Information

Chemical Name:4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester
CAS No.:108826-73-9
Molecular Formula:C₅₆H₈₁N₇O₁₁Si
Molecular Weight:1056.38
Hs Code.:

4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

Synonyms:4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

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Chemical Property of 4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

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Technology Process of 4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

There total 10 articles about 4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 108826-70-6
4-phenylalanylaminobutanoic acid 2-trimethylsilylethyl ester hydrochloride

: 108826-72-8
N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonine

: 108826-73-9
4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 4 ℃; for 16h;

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 108826-73-9
4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / DCC / pyridine

2: H₂ / 10percent Pd-C / propan-2-ol; acetic acid

3: 72 percent / 1.) HOBt, DCC; 2.) DIEA / dimethylformamide / 16 h / 4 °C

4: 76 percent / 3M HCl / ethyl acetate / 0.5 h / Ambient temperature

5: 65 percent / 1.) HOBt, DCC; 2.) DIEA / dimethylformamide / 16 h / 4 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In pyridine; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 3338-34-9
Z-Lys(-Boc)-Osu

: 108826-73-9
4-(N-α-benzyloxycarbonyl-D-tryptophyl-N-ε-t-butoxycarbonyl-lysyl-O-t-butylthreonylphenylalanyl)aminobutanoic acid 2-trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / NEt₃ / acetonitrile / 6 h / 20 °C

2: H₂ / 10percent Pd-C / propan-2-ol; acetic acid

3: 61 percent / 1.) HOBt, DCC; 2.) Et₃N / dimethylformamide / 16 h / 4 °C

4: 93 percent / Et₄NF / dimethylformamide / 0.5 h / 30 °C

5: 65 percent / 1.) HOBt, DCC; 2.) DIEA / dimethylformamide / 16 h / 4 °C

With hydrogen; tetraethylammonium fluoride; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;