N-Vinyl-2-pyrrolidone

Base Information

• Chemical Name: N-Vinyl-2-pyrrolidone
• CAS No.: 9003-39-8
• Deprecated CAS: 153631-60-8,94800-10-9,1229193-78-5,1229193-78-5,94800-10-9
• Molecular Formula: C6H9NO
• Molecular Weight: 16.04246
• Hs Code.: 39059990
• European Community (EC) Number: 201-800-4,607-660-4,618-363-4,658-049-4,658-051-5
• ICSC Number: 1478
• NSC Number: 683040,142693,114022,10222
• UNII: 76H9G81541
• DSSTox Substance ID: DTXSID2021440
• Nikkaji Number: J36.503C
• Wikipedia: N-Vinylpyrrolidone
• Wikidata: Q420628
• NCI Thesaurus Code: C77491,C80893
• RXCUI: 1307764,8610,1310706
• ChEMBL ID: CHEMBL1878943
• Mol file: 9003-39-8.mol

Synonyms:1-vinyl-2-pyrrolidone;N- vinyl pyrrolidone;N-vinyl-2-pyrrolidinone;N-vinylpyrrolidone

Chemical Property of N-Vinyl-2-pyrrolidone

Chemical Property:

• Appearance/Colour: white powder
• Melting Point: 130oC
• Boiling Point: 217.6 °C at 760 mmHg
• Flash Point: 93.9 °C
• PSA: 20.31000
• Density: 1.144g/cm³
• LogP: 0.69020
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: H2O: soluble100mg/mL
• Water Solubility.: Soluble in water.
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 111.068413911
• Heavy Atom Count: 8
• Complexity: 120

Purity/Quality:

99.9% ^*data from raw suppliers

Crospovidone~40,000 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Plastics & Rubber -> Other Monomers,Plastics & Rubber -> Polymers
• Canonical SMILES: C=CN1CCCC1=O
• Recent ClinicalTrials: Efficacy and Safety Assessment of Azyter? Eye Drops (T1225) in Patients With Blepharitis
• Recent EU Clinical Trials: Can a sinus rinse and mouth wash reduce viral load in COVID-19 positive individuals?
• Recent NIPH Clinical Trials: Study on reduction of salivary virus by povidone iodine on COVID-19
• Inhalation Risk: A harmful contamination of the air will be reached quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes. The substance is irritating to the respiratory tract.
• Effects of Long Term Exposure: The substance may have effects on the liver. This may result in liver impairment. Tumours have been detected in experimental animals but may not be relevant to humans.
• Uses: Clarifying agent; pigment stabilizer; colloidal stabilizer; It is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents. It is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L). Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; PVP of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine. Used as the fixing liquid for gas chromatography. It is used as a colloidal stabilizer and clarifying agent for beer clarification. Apply proper amount according the demands of production. It can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous. PolyFilterTM molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste. The products have two specifications: disposable type and regeneration type. Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since it is recyclable, it is suitable for large breweries for recycle application. In daily cosmetics, PVP and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye. Adding PVP to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect. Taking advantage of the excellent properties of PVP such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products. Polyvinylpyrrolidone is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels. It finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions. It is used as a food additive and in the wine industry as a fining agent for white wine. It is used as a capping agent to synthesize silver nanowires through a polyol process. Polyvinylpyrrolidone has been used:to perform intracytoplasmic sperm injection procedurein the preparation of endophyte coating agent mixture, to coat creeping bentgrass seedas a component of prehybridization solution
• Production method: Its crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction. Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h). The 30% to 60% aqueous solution of the purified 1-vinyl-2-pyrrolidone, in the presence of ammonia or amines and also with hydrogen peroxide as the catalyst, has cross-linking and homo-polymerization reaction at a temperature of 50 °C and subject to further purification to obtain the final product.

Technology Process of N-Vinyl-2-pyrrolidone

There total 4 articles about N-Vinyl-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ magnesium stearate (557-04-0) + polyvinylpyrrolidone (9003-39-8)

Guidance literature:

Reference yield:

1-ethenyl-2-pyrrolidinone (88-12-0) → polyvinylpyrrolidone (9003-39-8)

Guidance literature:

With dihydrogen peroxide; ammonia; copper(II) sulfate; 2,2'-iminobis[ethanol]; In water; at 80 ℃; for 8.5h; Conversion of starting material;

Reference yield:

→ polyvinylpyrrolidone (9003-39-8)

Guidance literature:

upstream raw materials:

1-ethenyl-2-pyrrolidinone

Downstream raw materials:

nipasol

methyl 4-hydroxylbenzoate

N-(diamino-[1,3,5]triazin-2-yl)-formamide

Refernces

• 1、 -. "Polyvinylpyrrolidone composition and processes for its production". Page/Page column 5-6. . Retrieved 2008/06/13.
• 2、 -. "Macromolecular microparticles and methods of production and use". . . Retrieved 2008/06/13.