Magnesium Stearate

Base Information

• Chemical Name: Magnesium Stearate
• CAS No.: 557-04-0
• Deprecated CAS: 212132-26-8
• Molecular Formula: 2(C18H35O2)^.Mg
• Molecular Weight: 591.254
• Hs Code.: HYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE Fine white to yellow-white powder
• European Community (EC) Number: 209-150-3
• ICSC Number: 1403
• UNII: 70097M6I30
• DSSTox Substance ID: DTXSID2027208
• Nikkaji Number: J43.178H
• Wikipedia: Magnesium_stearate
• Wikidata: Q416713
• NCI Thesaurus Code: C61820
• RXCUI: 1310567
• ChEMBL ID: CHEMBL2106633
• Mol file: 557-04-0.mol

Synonyms:aluminum monostearate;aluminum tristearate;ammonium stearate;calcium stearate;magnesium stearate;octadecanoic acid;sodium stearate;stearic acid;zinc stearate

Chemical Property of Magnesium Stearate

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 200 °C(lit.)
• Boiling Point: 359.4 °C at 760 mmHg
• Flash Point: 162.4 °C
• PSA: 52.60000
• Density: 1.028 g/cm³
• LogP: 12.50830
• Storage Temp.: Store at RT.
• Solubility.: alcohol: insoluble
• Water Solubility.: Insoluble
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 30
• Exact Mass: 590.5124524
• Heavy Atom Count: 41
• Complexity: 196

Purity/Quality:

99%, ^*data from raw suppliers

Magnesium stearate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Stearates
• Canonical SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
• Recent ClinicalTrials: Assessing the Effect of Shatavari Supplementation on Bone and Skeletal Muscle Health in Healthy Postmenopausal Women
• Inhalation Risk: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
• Uses: Magnesium stearate has been widely used for many decades in the food industry as an emulsifier, binder and thickener, as well as an anticaking, lubricant, release, and antifoaming agent. It is present in many food supplements, confectionery, chewing gum, herbs and spices, and baking ingredients. Magnesium stearate is also commonly used as an inactive ingredient in the production of pharmaceutical tablets, capsules and powders. The main reason for its good lubricating properties is its hydrophobic nature and an ability to reduce friction between tablets and die wall during the ejection process. Magnesium stearate can be regarded as being non-toxic, the United States, Germany and Japan allow it to be applied to products being contact with food. However, it doesn’t have wide application to be applied as PVC heat stabilizers. In China and some other countries Pharmacopoeia, there are always records of this specie. The pharmacopeia has also made provisions on the magnesium content, moisture, heavy metals, iron, sulfate and chloride content. widely used in the fields of the plastic, mold-releasing agent for tablets (need meeting the medicine criterion), emulsifying agents of cosmetics. It also can conjugate with Ca Soap as stabilizer of PVC. Magnesium Stearate is the magnesium salt of stearic acid which functions as a lubricant, binder, emulsifier, and anticaking agent. it is a white powder that is insoluble in water. it is used as a lubricant or die release in tableting pressed candies and is also used in sugar- less gum and mints. Magnesium stearate is often used as a anti-adherent in the manufacture of medical tablets, capsules and powders. In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets. Studies have shown that magnesium stearate may affect the release time of the active ingredients in tablets, etc., but not that it reduces the overall bioavailability of those ingredients. As a food additive or pharmaceutical excipient, its E number is E470b. Magnesium stearate is also used to bind sugar in hard candies like mints, and is a common ingredient in baby formulas. In pure powder form, the substance can be a dust explosion hazard, although this issue is effectively insignificant beyond the manufacturing plants using it. Magnesium stearate is manufactured from both animal and vegetable oils. Some nutritional supplements specify that the magnesium stearate used is sourced from vegetables. Magnesium stearate is a major component of "bathtub rings." When produced by soap and hard water, magnesium stearate and calcium stearate both form a white solid insoluble in water, and are collectively known as "soap scum.".
• Production method: Magnesium stearate is produced by the reaction of sodium stearate with magnesium salts or by treating magnesium oxide with stearic acid (Nora 2005). Magnesium stearate can be produced through the following procedure: first get the sodium stearate through the saponification between stearic acid and sodium; then the sodium stearate has double decomposition reaction with magnesium sulfate to get the finished product. Stearic acid and water was added to the reaction pot and heated to 85 ℃, stirring to dissolve, slowly add them to the sodium hydroxide solution preheated to 75 ℃. After the saponification reaction was completed, the temperature was controlled at 72 ℃ and slowly added to the magnesium sulfate solution preheated to 55 ℃ upon stirring. After metathesis, apply centrifuge to remove the water. The filtering cake was washed with water until sulfate ion requirement is met, then dry, apply air drying, sifting to obtain the finished products with the yield of stearic acid being 100%. It is produced through the combination reaction between magnesium oxide and food grade solid mixed fatty acids (mainly stearic acid) and further refinement.
• Description: Magnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C18H35O2)2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".

Technology Process of Magnesium Stearate

There total 13 articles about Magnesium Stearate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.23%

stearic acid (57-11-4) → magnesium stearate (557-04-0)

Guidance literature:

With magnesium oxide; dihydrogen peroxide; magnesium oxide; at 100 - 130 ℃; for 0.75h; Temperature;

Reference yield:

→ magnesium stearate (557-04-0) + stearic acid (57-11-4)

Guidance literature:

Reference yield:

→ mannitol (69-65-8) + magnesium stearate (557-04-0)

Guidance literature:

upstream raw materials:

mannitol

stearic acid

Downstream raw materials:

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

magnesium(II) oxalate

stearic acid

1-deoxy-1-(methylamino)-D-glucitol

Refernces

• 1、 -. "Magnesium stearate and preparation process thereof". Paragraph 0033-0037. . Retrieved 2018/02/04.
• 2、 -. "Use of selectively moisture-adjusted tabletting material in the production of mechanically stable tablets which contain at least one hydrate-forming active substance and/or adjuvant relevant to the mechanical stability of the tablets, particularly arginine-containing tablets". Page/Page column. . Retrieved 2014/04/18.