(6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

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Chemical Name:(6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one
CAS No.:474958-83-3
Molecular Formula:C₂₃H₃₆O₆Si
Molecular Weight:436.621
Hs Code.:

Synonyms:(6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

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Chemical Property of (6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

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Technology Process of (6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

There total 10 articles about (6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 474958-82-2
(1R)-1-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-but-3-enyl-3-phenylprop-2-enoate

: 474958-83-3
(6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

Guidance literature:: (Chx₃P)2Ru(1,3-Mes₂-tetrahydroimidazol-2-yl)Cl₂; In toluene; at 120 ℃; for 3h;
DOI:10.1021/jo0259358

Reference yield:

: (1R,2S)-1-(tert-butyldimethylsilyloxy)-2-(methoxyethoxymethoxy)-1-phenyl-hex-5-en-3-ol

: 474958-83-3
(6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / pyridine; DMAP / CH₂Cl₂ / 15 h / 0 °C

2: 77 percent / (Chx₃P)2Ru(1,3-Mes₂-tetrahydroimidazol-2-yl)Cl₂ / toluene / 3 h / 120 °C

With pyridine; dmap; (Chx₃P)2Ru(1,3-Mes₂-tetrahydroimidazol-2-yl)Cl₂; In dichloromethane; toluene;
DOI:10.1021/jo0259358

Reference yield:

: 77120-79-7
1-<(2-methoxyethoxy)methoxy>-2-propene

: 474958-83-3
(6R)-6-[(1S,2S)-2-(tert-butyldimethylsilyloxy)-1-(methoxyethoxymethoxy)-2-phenyl-ethyl]-5,6-dihydropyran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sec-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: BF₃*Et₂O / tetrahydrofuran / -100 °C

2.1: tetrahydrofuran / 2 h / -100 °C

3.1: 42.8 g / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 10 h / 25 °C

4.1: 89 percent / imidazole / dimethylformamide / 4 h / 20 °C

5.1: OsO₄; NMO / acetone; H₂O / 6 h / 0 °C

5.2: 50 percent / NaIO₄ / acetone; H₂O / 0.33 h / 20 °C

6.1: diethyl ether; pentane / 2 h / -100 °C

6.2: 73 percent / NaOH; H₂O₂ / diethyl ether; pentane; H₂O / 6 h / 20 °C

7.1: 70 percent / pyridine; DMAP / CH₂Cl₂ / 15 h / 0 °C

8.1: 77 percent / (Chx₃P)2Ru(1,3-Mes₂-tetrahydroimidazol-2-yl)Cl₂ / toluene / 3 h / 120 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; osmium(VIII) oxide; N-methyl-2-indolinone; dihydrogen peroxide; sec.-butyllithium; (Chx₃P)2Ru(1,3-Mes₂-tetrahydroimidazol-2-yl)Cl₂; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; pentane;
DOI:10.1021/jo0259358