1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Base Information

Chemical Name:1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine
CAS No.:475596-13-5
Molecular Formula:C₂₆H₂₃FN₄O
Molecular Weight:426.493
Hs Code.:

Synonyms:1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Suppliers and Price of 1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

There total 4 articles about 1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 475595-61-0
1,2-diphenyl-1H-imidazole-4-carboxylic acid

: 475596-13-5
1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm020848t

Reference yield:

: 1527-91-9
N-phenylbenzamidine

: 475596-13-5
1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / NaHCO₃ / propan-2-ol / 1.5 h / 70 °C

2: 94 percent / p-toluenesulfonic acid / toluene / 1.5 h / Heating

3: 80 percent / 1 N aq. NaOH / methanol / 1.5 h / Heating

4: 72 percent / DCC; HOBt / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; isopropyl alcohol; toluene;
DOI:10.1021/jm020848t

Reference yield:

: 475595-57-4
ethyl 1,2-diphenyl-1H-imidazole-4-carboxylate

: 475596-13-5
1-[(1,2-diphenyl-1H-imidazol-4-yl)carbonyl]-4-(2-fluorophenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1 N aq. NaOH / methanol / 1.5 h / Heating

2: 72 percent / DCC; HOBt / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jm020848t