(+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone

Base Information

• Chemical Name: (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone
• CAS No.: 134817-79-1
• Molecular Formula: C₁₉H₂₁NO₂Se
• Molecular Weight: 374.341
• Mol file: 134817-79-1.mol

Synonyms:(+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone

Chemical Property of (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone

There total 4 articles about (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene (72476-03-0) + N-(3-Furylmethylene)-3-(phenylseleno)propylamine (134817-78-0) → (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone (134817-79-1)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; for 40h; Ambient temperature;

DOI:10.1021/jo00016a033

Reference yield:

furan-3-carboxaldehyde (498-60-2) → (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone (134817-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄ / diethyl ether / 1 h / Ambient temperature

2: 72 percent / ZnCl₂ / tetrahydrofuran / 40 h / Ambient temperature

With magnesium sulfate; zinc(II) chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00016a033

Reference yield:

(E)-3-methyl-4-methoxy-3-buten-2-one (56279-34-6) → (+/-)-2-(3-Furyl)-2,3-dihydro-5-methyl-1-<3-(phenylseleno)propyl>-4-pyridinone (134817-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) LDA, 2) Et₃N / 1) THF, -78 deg C, 30 min, 2) a) -78 deg C, 10 min b) 1 h without cooling

2: 72 percent / ZnCl₂ / tetrahydrofuran / 40 h / Ambient temperature

With triethylamine; zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/jo00016a033

upstream raw materials:

(E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene

N-(3-Furylmethylene)-3-(phenylseleno)propylamine

furan-3-carboxaldehyde

(E)-3-methyl-4-methoxy-3-buten-2-one

Downstream raw materials:

(5α,7β,8α,8aα)-(+/-)-5-(3-Furyl)octahydro-8-methyl-7-(phenylseleno)indolizine