ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

Base Information

Chemical Name:ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate
CAS No.:130487-69-3
Molecular Formula:C₂₂H₃₀O₄
Molecular Weight:358.478
Hs Code.:

Synonyms:ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

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Chemical Property of ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

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Technology Process of ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

There total 4 articles about ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 487-51-4
4-carbethoxy-3-methyl-2-cyclohexen-1-one

: 39863-58-6
4-(2-bromoethyl)-2-isopropyl-1-methoxybenzene

: 130487-69-3
ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol;

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 130487-69-3
ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 1 h / 0 - 20 °C

1.2: 24 h / 120 °C

2.1: lithium bromide; ammonium cerium (IV) nitrate / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

3.2: 4 h / -78 - -10 °C / Inert atmosphere

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 20 °C / Inert atmosphere

5.2: 18 h / 75 °C / Inert atmosphere

With n-butyllithium; ammonium cerium (IV) nitrate; carbon tetrabromide; potassium tert-butylate; triphenylphosphine; lithium bromide; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.tet.2019.130774

Reference yield:

: 24591-33-1
4-bromo-2-isopropylanisole

: 130487-69-3
ethyl 3-(3-isopropyl-4-methoxyphenethyl)-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 4 h / -78 - -10 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 20 °C / Inert atmosphere

3.2: 18 h / 75 °C / Inert atmosphere

With n-butyllithium; carbon tetrabromide; potassium tert-butylate; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; tert-butyl alcohol;
DOI:10.1016/j.tet.2019.130774