(2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

Base Information

Chemical Name:(2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine
CAS No.:121964-27-0
Molecular Formula:C₂₇H₂₇NO₄
Molecular Weight:429.516
Hs Code.:

Synonyms:(2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

Suppliers and Price of (2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

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Technology Process of (2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

There total 1 articles about (2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 93-97-0
benzoic acid anhydride

: 121964-21-4
(1R,3S,4S,5R)-4-O-Benzyl-3-methyl-1-azabicyclo<3.1.0>hexan-4-ol

: 121964-27-0
(2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

Guidance literature:: In tetrahydrofuran; at -10 ℃; for 0.166667h;
DOI:10.1021/ja00201a033

Reference yield: 95.0%

: 121964-27-0
(2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

: 121964-34-9
(2R,3S,4S)-N-Benzoyl-3-(benzyloxy)-4-methylprolinol

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 14h;
DOI:10.1021/ja00201a033

Reference yield:

: 121964-27-0
(2R,3S,4S)-N-Benzoyl-1-<(benzoyloxy)methyl>-3-(benzyloxy)-4-methylpyrrolidine

: 121964-37-2
(2S,3S,4S)-N-Benzoyl-3-hydroxy-4-methylproline methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / CH₃ONa / methanol / 14 h / 20 °C

2: 1.) oxalyl chloride, DMSO, 2.) diisopropylethylamine / CH₂Cl₂ / -60 °C

3: aq. KMnO₄ / 2-methyl-propan-2-ol / 22 °C / phosphate buffer (pH 6)

4: diethyl ether / 0 °C

5: 94 percent / H₂, conc. HCl / Pd/C / methanol / 3 h / 22 °C / 2250.2 Torr

With hydrogenchloride; potassium permanganate; oxalyl dichloride; hydrogen; sodium methylate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja00201a033