(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
CAS No.:1373493-10-7
Molecular Formula:C₁₉H₁₃F₄N₃O₃S₂
Molecular Weight:471.456
Hs Code.:

Synonyms:(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

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Chemical Property of (S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

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Technology Process of (S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

There total 8 articles about (S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1239670-12-2
(S)-2-amino-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-methyl propanamide

: 96989-50-3
di-2-pyridyl thionocarbonate

: 1373493-10-7
(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 100 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ml3000269

Reference yield:

: 87310-69-8
N-(4-cyano-3-trifluoromethyl-phenyl)-2-oxo-propionamide

: 1373493-10-7
(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 40 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

2.2: -45 - -20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol; diethyl ether / -5 - 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; toluene;
DOI:10.1021/ml3000269

Reference yield:

: 1239669-98-7
S(S)-2-(tert-butylsulfinylimino)-N-(4-cyano-3-(trifluoromethyl)phenyl) propanamide

: 1373493-10-7
(S)-4-(4-((4-fluorophenylsulfonyl)methyl)-4-methyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Inert atmosphere

1.2: -45 - -20 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; diethyl ether / -5 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; toluene;
DOI:10.1021/ml3000269