1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one

Base Information

• Chemical Name: 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one
• CAS No.: 1253203-68-7
• Molecular Formula: C₂₃H₁₇N₃O
• Molecular Weight: 351.407
• Mol file: 1253203-68-7.mol

Synonyms:1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one

Chemical Property of 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one

There total 8 articles about 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

1-benzyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8-ol (1253203-66-5) → 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one (1253203-68-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 21h;

Reference yield:

4-dibenzocyclooctynol (1027338-06-2) + sym-dibenzo-1,5-cyclooctadiene-3,7-diyne (53397-65-2) + benzyl azide (622-79-7) → 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one (1253203-68-7) + 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-9(8H)-one (1253203-69-8) + 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole) (1253203-72-3) + C30H22N6 (1253203-73-4)

Guidance literature:

4-dibenzocyclooctynol; sym-dibenzo-1,5-cyclooctadiene-3,7-diyne; benzyl azide; In methanol; at 20 ℃; for 24h;

With Dess-Martin periodane; In methanol; chloroform; at 20 ℃; for 4h;

Reference yield:

3-hydroxy-1,2:5,6-dibenzocycloocta-1,5,7-triene (1144-71-4,77733-42-7) → 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one (1253203-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine / chloroform / 0.5 h / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / Inert atmosphere

4.1: methanol / 25 °C / Inert atmosphere

With bromine; Dess-Martin periodane; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; chloroform;

DOI:10.1002/cbic.201100117

upstream raw materials:

11,12-dibromo-5,6,11,12-tetrahydrodibenzo[a,e]cycloocten-5-ol

4-dibenzocyclooctynol

6H-11,12-didehydro-dibenzo[a,e]cyclooctatrien-5-one

benzyl azide