1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole)

Base Information

• Chemical Name: 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole)
• CAS No.: 1253203-72-3
• Molecular Formula: C₃₀H₂₂N₆
• Molecular Weight: 466.545
• Mol file: 1253203-72-3.mol

Synonyms:1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole)

Chemical Property of 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole)

There total 9 articles about 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.9%

sym-dibenzo-1,5-cyclooctadiene-3,7-diyne (53397-65-2) + benzyl azide (622-79-7) → 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole) (1253203-72-3) + C30H22N6 (1253203-73-4)

Guidance literature:

In dichloromethane; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo502248p

Reference yield:

4-dibenzocyclooctynol (1027338-06-2) + sym-dibenzo-1,5-cyclooctadiene-3,7-diyne (53397-65-2) + benzyl azide (622-79-7) → 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-8(9H)-one (1253203-68-7) + 1-benzyl-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-9(8H)-one (1253203-69-8) + 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole) (1253203-72-3) + C30H22N6 (1253203-73-4)

Guidance literature:

4-dibenzocyclooctynol; sym-dibenzo-1,5-cyclooctadiene-3,7-diyne; benzyl azide; In methanol; at 20 ℃; for 24h;

With Dess-Martin periodane; In methanol; chloroform; at 20 ℃; for 4h;

Reference yield:

ortho-(phenylsulfonylmethyl)benzonitrile (82651-72-7) → 1,8-dibenzyl-1,8-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole) (1253203-72-3) + C30H22N6 (1253203-73-4)

Guidance literature:

Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 °C / Inert atmosphere

2: diethyl chlorophosphate; lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

3: lithium diisopropyl amide / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4: dichloromethane / 2 h / 40 °C / Inert atmosphere

With diisobutylaluminium hydride; diethyl chlorophosphate; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo502248p

upstream raw materials:

sym-dibenzo-1,5-cyclooctadiene-3,7-diyne

benzyl azide

4-dibenzocyclooctynol

ortho-(phenylsulfonylmethyl)benzonitrile