1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

Base Information

Chemical Name:1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone
CAS No.:1431697-76-5
Molecular Formula:C₁₉H₂₅ClN₄O
Molecular Weight:360.887
Hs Code.:

Synonyms:1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

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Chemical Property of 1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

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Technology Process of 1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

There total 2 articles about 1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1374195-07-9
1-(4,6-dichloro-1-,5-naphthyridin-3-yl)ethanone

: trans-4-((dimethylamino)methyl)cyclohexan-1-amine diacetic acid

: 1431697-76-5
1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

Guidance literature:: With potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 60 - 100 ℃;

Reference yield:

: 1356953-43-9
benzyl 4-[(dimethylamino)methyl]cyclohexylcarbamate

: 1431697-76-5
1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine; potassium carbonate / 1,4-dioxane / 60 - 100 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol;

Reference yield: 79.0%

: 1431697-76-5
1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone

: 5720-07-0
4-methoxyphenylboronic acid

: 1-(4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-6-(4-methoxyphenyl)-1,5-naphthyridin-3-yl)ethanone dihydrochloride

Guidance literature:: 1-(6-chloro-4-{trans-4-[(dimethylamino)methyl]cyclohexylamino}-1,5-naphthyridin-3-yl)ethanone; 4-methoxyphenylboronic acid; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

With hydrogenchloride; In methanol; for 0.0833333h;