ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate

Base Information

• Chemical Name: ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate
• CAS No.: 1590412-90-0
• Molecular Formula: C₁₆H₂₀O₅
• Molecular Weight: 292.332
• Mol file: 1590412-90-0.mol

Synonyms:ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate

Chemical Property of ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate

There total 1 articles about ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

Ethyl levulinate ethylene ketal (941-43-5) + N-methoxy-N-methylbenzamide (6919-61-5) → ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate (1590412-90-0)

Guidance literature:

Ethyl levulinate ethylene ketal; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N-methoxy-N-methylbenzamide; In tetrahydrofuran; hexane; at -78 ℃; for 6h;

DOI:10.1002/chem.201304211

Reference yield: 75.0%

ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate (1590412-90-0) + methyl iodide (74-88-4) → ethyl 2-methyl-2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate (1590412-91-1)

Guidance literature:

ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 21h;

DOI:10.1002/chem.201304211

Reference yield:

ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate (1590412-90-0) → 4-methyl-4-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-phenylisoxazol-5(4H)-one (1590412-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 21 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 96 h / 95 °C

With hydroxylamine hydrochloride; sodium acetate; sodium hydride; In tetrahydrofuran; ethanol; water; mineral oil;

DOI:10.1002/chem.201304211

upstream raw materials:

Ethyl levulinate ethylene ketal

N-methoxy-N-methylbenzamide

Downstream raw materials:

4-methyl-4-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-phenylisoxazol-5(4H)-one

4-methyl-4-(2-oxopropyl)-3-phenylisoxazol-5(4H)-one

3,5-dimethyl-2-phenyl-1H-pyrrole

ethyl 2-methyl-2-((2-methyl-1,3-dioxolan-2-yl)methyl)-3-oxo-3-phenylpropanoate