(R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

Base Information

Chemical Name:(R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile
CAS No.:956320-20-0
Molecular Formula:C₂₃H₂₃Cl₂N₃O₃
Molecular Weight:460.36
Hs Code.:

Synonyms:(R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

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Chemical Property of (R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

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Technology Process of (R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

There total 8 articles about (R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 956320-16-4
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 956320-20-0
(R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 3h;

Reference yield:

: 956320-30-2
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 956320-20-0
(R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 4 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 3 h / 80 °C

With hydrogen; potassium carbonate; palladium hydroxide on carbon; In dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 956320-20-0
(R)-4-{3,5-dichloro-4-[1-(4-hydroxy-piperidin-1-yl)-2-oxo-pyrrolidin-3-ylmethyl]-phenoxy }-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 4 h / 20 °C

5.1: potassium carbonate / dimethyl sulfoxide / 3 h / 80 °C

With lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; sodium nitrite; palladium hydroxide on carbon; In tetrahydrofuran; 1,1-dichloroethane; water; dimethyl sulfoxide; ethyl acetate;