(4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

Base Information

Chemical Name:(4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol
CAS No.:179927-48-1
Molecular Formula:C₃₂H₄₂O₄Si
Molecular Weight:518.769
Hs Code.:

Synonyms:(4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

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Chemical Property of (4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

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Technology Process of (4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

There total 1 articles about (4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 179927-47-0
(5S,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-one

: 180061-44-3
(4R,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

: 179927-48-1
(4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -78 ℃; for 0.333333h;
DOI:10.1016/0040-4020(96)00383-3

Reference yield: 98.0%

: 179927-48-1
(4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

: 179927-57-2
(4S,5R,6S)-5-methyl-7-p-methoxybenzyloxy-1-hepten-4,6-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/0040-4020(96)00383-3

Reference yield:

: 179927-48-1
(4S,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-7-(4-methoxy-benzyloxy)-5-methyl-hept-1-en-4-ol

: (4S,5R,6S)-4-Allyl-6-benzenesulfonylmethyl-2,2,5-trimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / TBAF / tetrahydrofuran / 1 h / Ambient temperature

2: 83 percent / camphorsulfonic acid / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 83 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 0.33 h

4: 97 percent / pyridine, Bu₃P / 25 h / Ambient temperature

5: 51 percent / molecular sieves 4A, N-methylmorpholine N-oxide, tetrapropylammonium perruthenate / acetonitrile / 2 h / 40 °C

With pyridine; tetrapropylammonium perruthennate; tributylphosphine; 4 A molecular sieve; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/0040-4020(96)00383-3