(S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Base Information

Chemical Name:(S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1186606-47-2
Molecular Formula:C₂₆H₃₄N₄O₆
Molecular Weight:498.579
Hs Code.:

Synonyms:(S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of (S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of (S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

There total 6 articles about (S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-14-1
glycolic Acid

: 1186606-63-2
C₂₄H₃₂N₄O₄

: 1186606-47-2
(S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2016.03.020

Reference yield:

: 910635-33-5
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide

: 1186606-47-2
(S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 0.08 h / 20 °C

1.2: 1 h / 20 °C

2.1: 1,4-dioxane / 7 h / 100 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 21 h / 5 - 20 °C

4.1: ammonia / methanol / 16 h / 60 °C / Sealed tube

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / 20 °C

With ammonia; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2016.03.020

Reference yield:

: C₂₄H₂₉N₃O₄

: 1186606-47-2
(S)-N-(3-(2-ethyl-4-(5-(6-isobutyl-4-methoxypyridin-2-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 16 h / 60 °C / Sealed tube

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 2 h / 20 °C

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2016.03.020