4-Bromo-5-methyl-2,3-indolinedione

Base Information

• Chemical Name: 4-Bromo-5-methyl-2,3-indolinedione
• CAS No.: 147149-84-6
• Molecular Formula: C9H6BrNO2
• Molecular Weight: 240.056
• Hs Code.: 2933990090
• Mol file: 147149-84-6.mol

Synonyms:4-Bromo-5-methyl-2,3-indolinedione;4-Bromo-5-methyl-1H-indole-2,3-dione;Indole-2,3(2H,3H)-dione, 4-bromo-5-methyl-;Indoline-2,3-dione, 4-bromo-5-methyl-;AC1LD31X;AC1Q2D5N;

Chemical Property of 4-Bromo-5-methyl-2,3-indolinedione

Chemical Property:

• Refractive Index: 1.631
• PKA: 9.56±0.20(Predicted)
• PSA: 46.17000
• Density: 1.714 g/cm³
• LogP: 2.03030
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-5-methyl-1H-indole-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-52

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-5-methyl-2,3-indolinedione reagents used in the production of Nolatrexed Dihydrochloride.

Technology Process of 4-Bromo-5-methyl-2,3-indolinedione

There total 3 articles about 4-Bromo-5-methyl-2,3-indolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.7%

(E)-N-(3-bromo-4-methylphenyl)-2-(hydroxyimino)acetamide → 4-bromo-5-methyl-1H-indole-2,3-dione (147149-84-6) + 6-Bromo-5-methyl-1H-indole-2,3-dione (306325-13-3)

Guidance literature:

With sulfuric acid; at 80 ℃; for 1h;

DOI:10.1021/jm00058a010

Reference yield: 31.0%

→ 4-bromo-5-methyl-1H-indole-2,3-dione (147149-84-6) + 6-Bromo-5-methyl-1H-indole-2,3-dione (306325-13-3)

Guidance literature:

Reference yield:

N-(3-bromo-4-methyl-phenyl)-2-hydroxyimino-acetamide (147149-83-5) → 4-bromo-5-methyl-1H-indole-2,3-dione (147149-84-6) + 6-Bromo-5-methyl-1H-indole-2,3-dione (306325-13-3)

Guidance literature:

With sulfuric acid; at 80 ℃; for 0.25h;

DOI:10.1021/jm031016d

upstream raw materials:

N-(3-bromo-4-methyl-phenyl)-2-hydroxyimino-acetamide

Downstream raw materials:

6-amino-2-bromo-3-methyl-benzoic acid

methyl 2-amino-6-bromo-5-methylbenzoate

C₁₈H₁₃BrN₄O₃S

N'-(4-bromo-5-methyl-2-oxoindolin-3-ylidene)-3,4,5-trimethoxybenzohydrazide

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