2-AMINO-6-BROMO-5-METHYLBENZOIC ACID

Base Information

• Chemical Name: 2-AMINO-6-BROMO-5-METHYLBENZOIC ACID
• CAS No.: 147149-85-7
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.061
• Hs Code.: 2922499990
• Mol file: 147149-85-7.mol

Synonyms:2-Amino-6-bromo-5-methylbenzoic acid;

Chemical Property of 2-AMINO-6-BROMO-5-METHYLBENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.31E-05mmHg at 25°C
• Melting Point: 290-293 °C
• Refractive Index: 1.651
• Boiling Point: 353.6 °C at 760 mmHg
• PKA: 0.92±0.10(Predicted)
• Flash Point: 167.6 °C
• PSA: 63.32000
• Density: 1.682g/cm³
• LogP: 2.61910
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Amino-2-bromo-3-methylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-6-BROMO-5-METHYLBENZOIC ACID

There total 4 articles about 2-AMINO-6-BROMO-5-METHYLBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromo-5-methyl-1H-indole-2,3-dione (147149-84-6) → 6-amino-2-bromo-3-methyl-benzoic acid (147149-85-7)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; at 80 ℃; for 1h;

Reference yield: 97.8%

→ 6-amino-2-bromo-3-methyl-benzoic acid (147149-85-7)

Guidance literature:

Reference yield:

3-bromo-4-methylaniline (7745-91-7) → 6-amino-2-bromo-3-methyl-benzoic acid (147149-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / sodium sulfate, conc. HCl, hydroxylamine hydrochloride / H₂O / 1 h / 100 °C

2: 50.7 percent / conc. H₂SO₄ / 1 h / 80 °C

3: 98 percent / 3 N aq. NaOH, 30percent H₂O₂ / 1 h / 80 °C

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; sodium sulfate; In water;

DOI:10.1021/jm00058a010

upstream raw materials:

4-bromo-5-methyl-1H-indole-2,3-dione

3-bromo-4-methylaniline

Downstream raw materials:

2-guanidino-5-bromo-3,4-dihydro-6-methylquinazolin-4-one

2-amino-5-bromo-6-methyl-3-H-quinazolin-4-one

methyl 2-amino-6-bromo-5-methylbenzoate

4-[(3,4-Dihydro-2,6-dimethyl-4-oxo-5-quinazolinyl)thio]-benzoic acid

Refernces

• 1、 -. "CHEMICAL COMPOUNDS". Paragraph 0348; 1015-1016. . Retrieved 2019/06/20.
• 2、 -. "ANTIPROLIFERATIVE QUINAZOLINES". . . Retrieved 2008/06/13.