(R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Base Information

Chemical Name:(R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate
CAS No.:1448996-65-3
Molecular Formula:C₂₃H₂₈FN₇O₆
Molecular Weight:517.517
Hs Code.:

Synonyms:(R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

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Chemical Property of (R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

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Technology Process of (R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

There total 5 articles about (R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1071-46-1
hydrogen ethyl malonate

: 1448996-60-8
(R)-2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl) piperazin-1-yl)-2-oxoethanaminium 2,2,2-trifluoroacetate

: 1448996-65-3
(R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Guidance literature:: With oxalyl dichloride; triethylamine; In dichloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 1448996-58-4
C₂₃H₃₀FN₇O₅

: 1448996-65-3
(R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: triethylamine; oxalyl dichloride / acetonitrile; dichloromethane / 0 - 20 °C

With oxalyl dichloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 154590-64-4
(S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide

: 1448996-65-3
(R)-ethyl 3-((2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)piperazin-1-yl)-2-oxoethyl)amino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,2-dimethoxyethane / 90 °C

2.1: dichloromethane / 0 - 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: dichloromethane / 0 - 20 °C

5.1: triethylamine; oxalyl dichloride / acetonitrile; dichloromethane / 0 - 20 °C

With oxalyl dichloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041