(6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

Base Information

Chemical Name:(6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester
CAS No.:1117752-16-5
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:(6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

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Chemical Property of (6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

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Technology Process of (6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

There total 1 articles about (6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (6R,7R)-rel-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

: 1117752-16-5
(6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

: 1117752-19-8
(6R,7R)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

Guidance literature:: With amylose tris(3,5-dimethylphenylcarbamate) coated on 20 μm silica support; In ethanol; optical yield given as %ee; enantioselective reaction; Resolution of racemate;
DOI:10.1021/jm801211c

Reference yield:

: 1117752-16-5
(6S,7S)-(1-methylethyl)-(4,5,6,7-tetrahydro-7-hydroxy-2-oxoimidazo[4,5,1-jk][1]benzazepin-6-yl)carbamic acid phenylmethyl ester

: 1001395-75-0
(6S,7S)-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]imidazo[4,5,1-jk][1]benzazepin-2(1H)-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In 1,4-dioxane; water; at 20 ℃; for 5h; under 3000.3 Torr;
DOI:10.1021/jm801211c