(1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

Base Information

Chemical Name:(1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol
CAS No.:1315306-97-8
Molecular Formula:C₂₇H₂₈BrNO₄S
Molecular Weight:542.494
Hs Code.:

Synonyms:(1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

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Chemical Property of (1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

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Technology Process of (1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

There total 5 articles about (1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1315306-89-8
1-(1-[(4-methylphenyl)sulfonyl]-5-phenyl-4-[(E)-2-phenylethen-1-yl]tetrahydro-1H-pyrrol-3-yl)-1-ethanone

: 1315306-97-8
(1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

Guidance literature:: With N-Bromosuccinimide; water; In acetone; at 20 ℃; for 4h;
DOI:10.1002/anie.201101389

Reference yield:

: 1269141-77-6
(1R,4R,5R,6R)-6-benzyl-4,7,7-trimethyl-6-thiabicyclo[3.2.1]octan-6-ium trifluoromethanesulfonate

: 1315306-97-8
(1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 0 - 20 °C

2.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾-chloroform; tetrabutyl-ammonium chloride; tris-(o-tolyl)phosphine / tert-butyl methyl ether; pentane / 0.33 h / 20 °C

2.2: 24 h / 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide; water / acetone / 4 h / 20 °C

With N-Bromosuccinimide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾-chloroform; tetrabutyl-ammonium chloride; water; potassium carbonate; tris-(o-tolyl)phosphine; In tert-butyl methyl ether; acetone; acetonitrile; pentane;
DOI:10.1002/anie.201101389

Reference yield:

: 911028-87-0
(2R,3R)-2-phenyl-3-[(E)-2-phenyl-1-ethenyl]-1-tosylaziridine

: 1315306-97-8
(1S,3aR,4S,7S,7aS)-7-bromo-4-methyl-2-[(4-methylphenyl)sulfonyl]-1,6-diphenylperhydropyrano[3,4-c]pyrrol-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾-chloroform; tetrabutyl-ammonium chloride; tris-(o-tolyl)phosphine / tert-butyl methyl ether; pentane / 0.33 h / 20 °C

1.2: 24 h / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide; water / acetone / 4 h / 20 °C

With N-Bromosuccinimide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾-chloroform; tetrabutyl-ammonium chloride; water; tris-(o-tolyl)phosphine; In tert-butyl methyl ether; acetone; pentane;
DOI:10.1002/anie.201101389