Chemical Property of 6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-beta-cyclodextrin
Chemical Property:
- Appearance/Colour:white powder
- Melting Point:278oC (dec.)
- Refractive Index:125 ° (C=1, H2O)
- Boiling Point:400℃
- PSA：618.66000
- Density:1.05 at 20.3℃
- LogP:-12.39490
- Storage Temp.:2-8°C
- Solubility.:H2O: 45 % (w/v)
- Water Solubility.:Soluble in water.
- XLogP3:-13
- Hydrogen Bond Donor Count:21
- Hydrogen Bond Acceptor Count:42
- Rotatable Bond Count:28
- Exact Mass:1540.6628176
- Heavy Atom Count:105
- Complexity:2010
- Purity/Quality:
-
99% *data from raw suppliers
2-Hydroxypropyl-β-cyclodextrin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:UVCB,Other Classes -> Other Organic Compounds
- Canonical SMILES:CC(COCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)COCC(C)O)O)O)O
- Recent EU Clinical Trials:A Randomized, Placebo-controlled, Double-blind, Parallel group, 6 Month Study to Evaluate the Safety, Tolerability, and Potential Efficacy of Monthly Trappsol? Cyclo? (hydroxypropyl beta cyclodextrin, HPβCD) Infusions in Patients With Early Alzheimer’s Disease: A dose -range finding study
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Uses
2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin. enteric coating, sustained release formulations, buccal and transdermal drug delivery 2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
