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Basic Information
CAS No.: 128446-35-5
Name: (2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
Molecular Structure:
Molecular Structure of 128446-35-5 ((2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN)
Formula: Unspecified
Molecular Weight: 1541.54000
Synonyms: Hydroxypropyl-beta-cyclodextrin;
EINECS: 420-920-1
Density: 1.05 at 20.3℃
Melting Point: 278oC (dec.)
Boiling Point: 400℃
Solubility: Soluble in water.
Appearance: white powder
Safety: 24/25
PSA: 618.66000
LogP: -12.39490
Synthetic route
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C105H196O56*2C47H51NO14

Conditions
ConditionsYield
In ethanol at 30℃; for 24h;
2224-15-9

ethylene glycol diglycidyl ether

hydroxypropyl methylcellulose

hydroxypropyl methylcellulose

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

polymer, cross-linked; monomers: hydroxypropyl-β-cyclodextrin; hydroxypropylmethylcellulose; ethyleneglycol diglycidyl ether

polymer, cross-linked; monomers: hydroxypropyl-β-cyclodextrin; hydroxypropylmethylcellulose; ethyleneglycol diglycidyl ether

Conditions
ConditionsYield
In sodium hydroxide at 20 - 50℃;
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C18H28N2O*C105H196O56*ClH

Conditions
ConditionsYield
In water-d2
80-12-6

Tetramethylenedisulfotetramine

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C4H8N4O4S2*C105H196O56

Conditions
ConditionsYield
In water-d2 at 30℃;
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

132203-70-4

cilnidipine

C105H196O56*C27H28N2O7

Conditions
ConditionsYield
In water at 20℃; for 24h;
144701-48-4

telmisatran

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C33H30N4O2*C105H196O56

Conditions
ConditionsYield
In water at 37℃; for 24h; pH=10;
151319-34-5

zaleplon

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

C105H196O56*C17H15N5O

Conditions
ConditionsYield
In water-d2 at 21.84℃; Thermodynamic data;
128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
1806-26-4

p-Octylphenol

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
104-40-5

4-Nonylphenol

128446-35-5

heptakis-(2,3,6-tris-(2-hydroxypropyl))-β-cyclodextrin

(2-hydroxypropyl)-β-cyclodextrin

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃;
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Chemistry

Molecule structure of 2-Hydroxypropyl-beta-cyclodextrin (CAS NO.128446-35-5):

Molecular Formula: C42.(H)70-n.O35.(C3H7)n 
Melting Point: 278 °C (dec.)
Refractive Index: 125 ° (C=1, H2O)
Storage Temp.: 2-8 °C
Water Solubility: 45 % (w/v)
Appearance: white to slightly yellow powder
EINECS: 420-920-1
Product Categories of 2-Hydroxypropyl-beta-cyclodextrin (CAS NO.128446-35-5): Biochemistry; Cyclodextrins; Functional Materials; Macrocycles for Host-Guest Chemistry; Oligosaccharides; Sugars; Chelation/Complexation Compounds; Synthetic Reagents; CyclodextrinsCell Culture; CyclodextrinsSynthetic Reagents; Cell Signaling and Neuroscience; Lipids and Lipid Carriers; Reagents and Supplements; Signal Transduction Research Tools

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 5gm/kg (5000mg/kg)   Journal of Pharmaceutical Sciences. Vol. 84, Pg. 1223, 1995.
 

Safety Profile

WGK Germany: 3
RTECS: GU2293332

Specification

 2-Hydroxypropyl-beta-cyclodextrin (CAS NO.128446-35-5) is also named as HPB ; UNII-1I96OHX6EK ; beta-Hydroxypropylcyclodextrin ; beta-Cyclodextrin, 2-hydroxypropyl ether ; Hydroxypropyl-beta-cyclodextrin .