Dimethyl sulfone

Base Information

• Chemical Name: Dimethyl sulfone
• CAS No.: 67-71-0
• Deprecated CAS: 54841-73-5,1800084-98-3
• Molecular Formula: C2H6O2S
• Molecular Weight: 94.1344
• Hs Code.: 29309070
• European Community (EC) Number: 200-665-9
• NSC Number: 63345
• UNII: 9H4PO4Z4FT
• DSSTox Substance ID: DTXSID4043937
• Nikkaji Number: J1.130.893G,J1.412E
• Wikipedia: Methylsulfonylmethane
• Wikidata: Q423842
• NCI Thesaurus Code: C84616
• RXCUI: 23247
• Metabolomics Workbench ID: 38684
• ChEMBL ID: CHEMBL25028
• Mol file: 67-71-0.mol

Synonyms:dimethyl sulfone;dimethyl sulfone, 13C-labeled;methyl sulfone;methyl sulfonmethane;methylsulfonylmethane

Chemical Property of Dimethyl sulfone

Chemical Property:

• Appearance/Colour: colourless crystals
• Vapor Pressure: 0.0573mmHg at 25°C
• Melting Point: 107-109 °C(lit.)
• Refractive Index: 1.4775 - 1.4790
• Boiling Point: 240.9 °C at 760 mmHg
• PKA: 28(at 25℃)
• Flash Point: 132.7 °C
• PSA: 42.52000
• Density: 1.139 g/cm³
• LogP: 0.74160
• Storage Temp.: Store below +30°C.
• Solubility.: 150g/l
• Water Solubility.: 150 g/L (20 ºC)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 94.00885060
• Heavy Atom Count: 5
• Complexity: 85.3

Purity/Quality:

99.95% ^*data from raw suppliers

Dimethyl Sulfone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Sulfur Compounds
• Canonical SMILES: CS(=O)(=O)C
• Recent ClinicalTrials: The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health
• description: Dimethyl Sulfone (MSM) is an organic sulfur-containing compound that occurs naturally in a variety of fruits, vegetables, grains, and animals including humans. a white, odorless, slightly bitter-tasting crystalline substance containing 34-percent elemental sulfur, MSM is a normal oxidative metabolite product of dimethyl sulfoxide (DMSO). Cow’s milk is the most abundant source of MSM, containing approximately 3.3 parts per million (ppm). Other foods containing MSM are coffee (1.6 ppm), tomatoes (trace to 0.86 ppm), tea (0.3 ppm), Swiss chard (0.05-0.18 ppm), beer (0.18 ppm), corn (up to 0.11 ppm), and alfalfa (0.07 ppm).MSM has been isolated from plants such as Equisetum arvense, also known as horsetail. Dimethyl Sulfone has the ability to enhance the body to produce insulin, while it can promote carbohydrate metabolism. It is essential for the synthesis of human collagen. It can not only promote wound healing, but also contribute for metabolic and neurological health requirement of vitamin B and vitamin C, biotin synthesis and activation, so it is known as "naturally beautiful carbon material". Dimethyl Sulfone exists in human skin, hair, nails, bones, muscles and various organs. Once people who are lack of it will get health disorders or diseases. It is the main substance for people to maintain the balance of biological sulfur. It has therapeutic value and healthcare function for people. It is an essential drug for human survial and health protection.
• Uses: Use as high temperature solvent inorganic and organic substances, organic chemical raw materials, food additives and health products raw materials, also used as gas chromatography stationary phase (maximum use temperature 30 ℃, acetone as solvent) and analytical reagents. antiinflammatory, antiproliferative, antiparasitic Dimethyl sulfone is a high tempereture solvent for many inorganic and organic substances,it is used as antiinflammatory, antiproliferative, antiparasitic. Dimethyl sulfone is used as a high-temperature solvent for both inorganic and organic substances. It acts as an intermediate as well as medium in organic synthesis. It plays an important role as a carbon source by the airborne bacteria Afipia. It is also employed as an extraction solvent for the separation of aromatic compounds like benzene, toluene and xylenes from aliphatic hydrocarbons. Further, it is used in the polymerization process. It finds application in pharmaceuticals, agrochemicals, paint and coating materials.

Technology Process of Dimethyl sulfone

There total 95 articles about Dimethyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethyl sulfoxide (67-68-5,8070-53-9) → dimethylsulfone (67-71-0)

Guidance literature:

With sodium molybdate dihydrate; dihydrogen peroxide; In methanol; water; at 25 ℃; for 0.5h; Concentration; Kinetics;

DOI:10.1016/j.tetlet.2010.10.022

Reference yield: 100.0%

dimethylsulfide (75-18-3) → dimethylsulfone (67-71-0)

Guidance literature:

With sodium periodate; ruthenium-carbon composite; In water; at 20 ℃; for 2h;

Reference yield: 95.0%

cyclohexenone (930-68-7) + CH3SO2CH2CuCH3(1-)*Li(1+)=(CH3SO2CH2CuCH3)Li → dimethylsulfone (67-71-0) + 3-Methylcyclohexanone (591-24-2,625-96-7)

Guidance literature:

With ammonium chloride; In tetrahydrofuran; at 0 ℃;

DOI:10.1039/c39820000358

upstream raw materials:

dimethylsulfide

2-(methylsulfonyl)acetic acid

sulfonyldiacetic acid

1-methyl-4-nitrosobenzene

Downstream raw materials:

2-methylsulfonyl-1-phenylethanone

3-(4-chloro-phenyl)-2-methylsulfanyl-4,5-dihydro-3H-benzo[b]azepine

2-(methylsulfonyl)-1-(3-nitrophenyl)-1-ethanone

N-phenyl-2-methylsulphonyl-1-phenylethylamine

Refernces

• 1、 Lyavinets,Marushchak. "Kinetics and mechanism of oxidation of dimethyl sulfoxide with benzoyl peroxide in superbasic media". . p. 885 - 889. Retrieved 2004.
• 2、 Petrov, Viacheslav,Marshall, Will. "Synthesis of new polyfluorinated oxaziridines". . p. 1 - 6. Retrieved 2018.
• 3、 Choban,Yurchuk,Lyavinets. "Oxidation of dimethyl sulfoxide with hydrogen peroxide in the presence of potassium hydroxide". . p. 2071 - 2074. Retrieved 2008.
• 4、 Choban,Yurchuk,Lyavinets. "Effect of base nature on the oxidation of dimethyl sulfoxide with hydrogen peroxide in superbasic media". . p. 247 - 250. Retrieved 2012.
• 5、 Das, Asim K.,Mondal, Sudhin K.,Kar, Dalia,Das, Mahua. "Kinetics and Mechanism of Picolinic Acid Promoted Chromium(vl) Oxidation of Dimethyl Sulfoxide in the Presence and Absence of Surfactants". . p. 574 - 575. Retrieved 1998.
• 6、 D?ren, René,Hartmann, Jens,Leibauer, Benjamin,Panth?fer, Martin,Mondeshki, Mihail,Tremel, Wolfgang. "Magneli-type tungsten oxide nanorods as catalysts for the selective oxidation of organic sulfides". . p. 14027 - 14037. Retrieved 2021/10/19.
• 7、 -. "Synthesis method of sulfone compound". Paragraph 0025-0029. . Retrieved 2020/01/25.