methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

Base Information

Chemical Name:methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate
CAS No.:801239-76-9
Molecular Formula:C₄₀H₅₈FN₃O₁₂
Molecular Weight:791.912
Hs Code.:

methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

Synonyms:methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

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Chemical Property of methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

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Technology Process of methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

There total 4 articles about methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 3160-47-2
N-(benzyloxycarbonyl)-L-aspartic acid 4-methyl ester

: 801239-74-7
3-[(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propylamino)-methyl]-4-fluoro-benzoic acid tert-butyl ester

: 801239-76-9
methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049666k

Reference yield:

: 193473-82-4
tert-butyl-4-fluoro-3(alpha-bromomethyl)benzoate

: 801239-76-9
methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / dimethylformamide / 20 °C

2: 88 percent / EDC; HOBT / dimethylformamide

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049666k

Reference yield:

: 194920-62-2
tert-butyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate

: 801239-76-9
methyl (S)-3-(N-(3-(2-(2-(3-((tert-butoxy)carbonyl amino)propoxy)ethoxy)ethoxy)propyl)-N-((5-((tert-butyl)oxy carbonyl)-2-fluorophenyl)methyl)carbamoyl)-3-((phenylmethoxy)carbonylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / dimethylformamide / 20 °C

2: 88 percent / EDC; HOBT / dimethylformamide

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049666k