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(+/-)-Epicatechin

Base Information Edit
  • Chemical Name:(+/-)-Epicatechin
  • CAS No.:490-46-0
  • Molecular Formula:C15H14 O6
  • Molecular Weight:290.273
  • Hs Code.:29329990
  • NSC Number:81162,81161
  • Nikkaji Number:J3.322.115K
  • Wikidata:Q105207974
  • Mol file:490-46-0.mol
(+/-)-Epicatechin

Synonyms:Epicatechol, (-)-;(.+-.)-Epicatechol;SCHEMBL13350313;NSC81162;NSC-81162;2H-1-Benzopyran-3,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-

Suppliers and Price of (+/-)-Epicatechin
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (-)-Epicatechin
  • 1g
  • $ 140.00
  • TCI Chemical
  • (-)-Epicatechin >97.0%(HPLC)
  • 5g
  • $ 327.00
  • TCI Chemical
  • (-)-Epicatechin >97.0%(HPLC)
  • 1g
  • $ 109.00
  • Sigma-Aldrich
  • (?)-Epicatechin ≥98% (HPLC), from green tea
  • 1mg
  • $ 44.50
  • Sigma-Aldrich
  • (?)-Epicatechin analytical standard
  • 10mg
  • $ 349.00
  • Sigma-Aldrich
  • Epicatechin primary reference standard
  • 10mg
  • $ 349.00
  • Sigma-Aldrich
  • (?)-Epicatechin ≥98% (HPLC), from green tea
  • 5mg
  • $ 155.00
  • Sigma-Aldrich
  • (?)-Epicatechin ≥90% (HPLC)
  • 1g
  • $ 153.00
  • Sigma-Aldrich
  • (?)-Epicatechin ≥90% (HPLC)
  • 5g
  • $ 536.00
  • Medical Isotopes, Inc.
  • (-)-Epicatechin
  • 10 mg
  • $ 650.00
Total 176 raw suppliers
Chemical Property of (+/-)-Epicatechin Edit
Chemical Property:
  • Appearance/Colour:White to light yellow crystal powder 
  • Melting Point:240 °C (dec.)(lit.) 
  • Boiling Point:630.4 °C at 760 mmHg 
  • PKA:9.54±0.10(Predicted) 
  • Flash Point:335°C 
  • PSA:110.38000 
  • Density:1.593g/cm3 
  • LogP:1.54610 
  • Storage Temp.:2-8°C 
  • Solubility.:insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO 
  • Water Solubility.:Soluble in water or alcohol 
  • XLogP3:0.4
  • Hydrogen Bond Donor Count:5
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:1
  • Exact Mass:290.07903816
  • Heavy Atom Count:21
  • Complexity:364
Purity/Quality:

98%min *data from raw suppliers

(-)-Epicatechin *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
  • Isomeric SMILES:C1[C@H](C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
  • Description (?)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay when used at a concentration of 5 μM. (?)-Epicatechin inhibits COX-1 (IC50 = 3.2 μM). It acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 μM. (?)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.
  • Uses Catechin is a polyphenolic flavonoid that has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid peroxidation assays. (?)-Epicatechin is a 2R,3R stereoisomer of catechin. Like catechin, (?)-epicatechin is a powerful antioxidant. It inhibits cyclooxygenase 1 (IC50 = 3.2 μM). Also, at 100 μM, (?)-epicatechin induces apoptosis in human adenocarcinoma PC-9 cells and stimulates the inhibition of tumor necrosis factor-α release from BALB-c/3T3 cells treated with epigallocatechin gallate. An antioxidant and natural product from green tea
Technology Process of (+/-)-Epicatechin

There total 169 articles about (+/-)-Epicatechin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; sodium cyanoborohydride; In methanol; for 6h;
Guidance literature:
With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 - 55 ℃;
Guidance literature:
With hydrogenchloride; sodium cyanoborohydride; In methanol; for 24h;
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