methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

Base Information

Chemical Name:methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate
CAS No.:1301601-42-2
Molecular Formula:C₁₈H₂₂F₃NO₄
Molecular Weight:373.372
Hs Code.:

Synonyms:methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

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Chemical Property of methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

Chemical Property:

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Technology Process of methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

There total 6 articles about methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1301601-30-8
C₁₄H₁₅F₃O₅

: 1301601-42-2
methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;
DOI:10.1002/chem.201003591

Reference yield:

: 1301601-28-4
methyl 2-(allyloxy)-2-(4-trifluoromethylphenyl)acetate

: 1301601-42-2
methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 336 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol; water / 0.5 h / 20 °C / Inert atmosphere

3: chromium(VI) oxide; sulfuric acid / water; acetone / 2 h / 20 °C / Inert atmosphere

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sodium tetrahydroborate; Hoveyda-Grubbs catalyst second generation; nickel(II) chloride hexahydrate; sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; water; acetone;
DOI:10.1002/chem.201003591

Reference yield:

: C₁₄H₁₃F₃O₄

: 1301601-42-2
methyl 2-(4-oxo-4-(pyrrolidin-1-yl)butoxy)-2-(4-(trifluoromethyl)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; nickel(II) chloride hexahydrate / methanol; water / 0.5 h / 20 °C / Inert atmosphere

2: chromium(VI) oxide; sulfuric acid / water; acetone / 2 h / 20 °C / Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 72 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; sodium tetrahydroborate; nickel(II) chloride hexahydrate; sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; water; acetone;
DOI:10.1002/chem.201003591