3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Name:3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one
CAS No.:1574541-90-4
Molecular Formula:C₂₈H₃₃NO₅
Molecular Weight:463.574
Hs Code.:

Synonyms:3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Property of 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Technology Process of 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

There total 8 articles about 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.3%

: 1574541-89-1
N-allyl-2-(4-cyclopropylphenoxy)-N-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)but-2-enamide

: 1574541-90-4
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1574541-77-7
methyl 2-(4-cyclopropylphenoxy)but-2-enoate

: 1574541-90-4
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0 - 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C

3.2: 0 - 20 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 16 h / 70 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium hydroxide monohydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 34105-70-9
2-Ethyl-4-nitrophenol

: 1574541-90-4
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 16 h / Reflux

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C / 7500.75 Torr / Autoclave

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C

4.2: 0 - 20 °C

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 16 h / 70 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 5%-palladium/activated carbon; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;