2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

Base Information

Chemical Name:2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate
CAS No.:1574541-92-6
Molecular Formula:C₂₄H₂₇NO₆S
Molecular Weight:457.547
Hs Code.:

Synonyms:2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

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Chemical Property of 2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

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Technology Process of 2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

There total 10 articles about 2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1574541-91-5
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-hydroxyethoxy)phenyl)-1H-pyrrol-2(5H)-one

: 124-63-0
methanesulfonyl chloride

: 1574541-92-6
2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 1574541-77-7
methyl 2-(4-cyclopropylphenoxy)but-2-enoate

: 1574541-92-6
2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0 - 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C

3.2: 0 - 20 °C

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 16 h / 70 °C / Inert atmosphere

5.1: methanesulfonic acid / methanol / 0 - 25 °C

6.1: triethylamine / dichloromethane / 0 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfonic acid; lithium hydroxide monohydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 34105-70-9
2-Ethyl-4-nitrophenol

: 1574541-92-6
2-(4-(3-(4-cyclopropylphenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-2-ethylphenoxy)ethyl methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 16 h / Reflux

2.1: hydrogen; 5%-palladium/activated carbon / methanol / 3 h / 20 °C / 7500.75 Torr / Autoclave

3.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 20 °C

4.2: 0 - 20 °C

5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 16 h / 70 °C / Inert atmosphere

6.1: methanesulfonic acid / methanol / 0 - 25 °C

7.1: triethylamine / dichloromethane / 0 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfonic acid; 5%-palladium/activated carbon; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;