2,2-Difluoroacetohydrazide

Base Information

• Chemical Name: 2,2-Difluoroacetohydrazide
• CAS No.: 84452-98-2
• Molecular Formula: C₂H₄F₂N₂O
• Molecular Weight: 110.063
• European Community (EC) Number: 817-779-5
• DSSTox Substance ID: DTXSID20902451

Synonyms:2,2-difluoroacetohydrazide;84452-98-2;Acetic acid, difluoro-, hydrazide;difluoroacetyl hydrazine;NoName_1694;difluoro-acetic acid hydrazide;SCHEMBL2037276;DTXSID20902451;MFCD22413557;AKOS027324635;SB85827;AS-58671;CS-0523673;EN300-127704

Chemical Property of 2,2-Difluoroacetohydrazide

Chemical Property:

• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 110.02916908
• Heavy Atom Count: 7
• Complexity: 74.1

Purity/Quality:

99% ^*data from raw suppliers

2,2-Difluoroacetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(C(=O)NN)(F)F

Technology Process of 2,2-Difluoroacetohydrazide

There total 4 articles about 2,2-Difluoroacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl difluoroacetate (454-31-9) → 2,2-difluoroacetohydrazide (84452-98-2)

Guidance literature:

With hydrazine; In ethanol; at 20 - 80 ℃; for 4h;

Reference yield:

benzyl 2-(difluoroacetyl)hydrazinecarboxylate → 2,2-difluoroacetohydrazide (84452-98-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃;

DOI:10.1007/s10593-016-1845-3

Reference yield:

difluoroacetic acid methyl ester (433-53-4) → 2,2-difluoroacetohydrazide (84452-98-2)

Guidance literature:

With hydrazine; In methanol; for 1.25h;

upstream raw materials:

ethyl difluoroacetate

difluoroacetic acid methyl ester

Downstream raw materials:

4-Benzyl-3-difluoromethyl-5-methyl-4H-1,2,4-triazole

7-bromo-1-(difluoromethyl)-8-phenyl-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazine

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