433-53-4

Basic information

• Product Name: METHYL DIFLUOROACETATE
• Synonyms: Difluoroacetic acid methyl ester, Methyl 2,2-difluoroethanoate;METHYL DIFLUOROACETATE;ART-CHEM-BB B020262;DIFLUOROACETIC ACID METHYL ESTER;AKOS B020262;Acetic acid, difluoro-, methyl ester;ethanoicacid,difluoro-,methylester;Methyldifluoroacetate,99%
• CAS NO: 433-53-4
• Molecular Formula: C₃H₄F₂O₂
• Molecular Weight: 110.06
• EINECS: 207-089-7
• Product Categories: Pyridines;C2 to C5;Carbonyl Compounds;Esters;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Difluoromethyl;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks
• Mol File: 433-53-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 85-86 °C(lit.)
• Flash Point: 75 °F
• Appearance: /
• Density: 1.26 g/mL at 25 °C(lit.)
• Vapor Pressure: 2220mmHg at 25°C
• Refractive Index: n20/D 1.334(lit.)
• Water Solubility: Slightly soluble in water.
• BRN: 1747534
• CAS DataBase Reference: METHYL DIFLUOROACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL DIFLUOROACETATE(433-53-4)
• EPA Substance Registry System: METHYL DIFLUOROACETATE(433-53-4)

Safety Data

• Hazard Codes: Xn,F
• Statements: 10-20/21/22-36/37/38
• Safety Statements: 16-23-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 433-53-4(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

A methyl difluoroacetate (MFA)-based LiPF6 solution was applied as an electrolyte to improve the thermal stability of Li-ion batteries. Methyl difluoroacetate is used in the inhibition of corrosion of aluminum cathode current collector for lithium ion cells.

General Description

The gas-phase reactions of Cl atoms with methyl difluoroacetate have been investigated at 296 ± 2K and atmospheric pressure of synthetic air.

InChI:InChI=1/C3HF5/c4-1(2(5)6)3(7)8/h2H

Upstream product

• 109872-87-9 methyl difluoroiodoacetate 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 67-56-1 methanol 
• 354-24-5 chlordifluoroacetyl chloride 
• 1514-87-0 metyhyl chlorodifluoroacetate 
• 425-88-7 1,1,2,2-tetrafluoro-1-methoxyethane 
• 2925-22-6 2,2-difluoroacetyl fluoride 
• 123771-68-6 poly-{(methyl difluoroacetate)copper} 
• 4111-54-0 lithium diisopropyl amide 
• 100-52-7 benzaldehyde 
• 75-77-4 chloro-trimethyl-silane 
• 104-53-0 3-phenyl-propionaldehyde 
• 186581-53-3 diazomethane 
• 60-29-7 diethyl ether 

Downstream Products

• 381-73-7 Difluoroacetic acid 
• 705939-70-4 C₁₄H₁₄F₂O₄ 
• 84452-98-2 2,2-difluoroacetohydrazide 
• 117710-72-2 1,1-difluoro-4-phenylbut-3-yn-2-one 
• 130728-23-3 2,2-difluoro-1-(4-methoxyphenyl)ethan-1-ol 
• 129660-32-8 difluoroacetaldehyde methyl hemiacetal 
• 148992-43-2 1-ethoxy-2,2-difluoroethanol 
• 705-09-9 2-(difluoromethyl)-1H-benzo[d]imidazole 
• 359-13-7 difluoroethanol 
• 1261289-79-5 4,4-difluoro-3-oxobutanenitrile 
• 352-24-9 ethyl 4,4-difluoro-3-oxobutyrate 
• 155094-63-6 N-Ethyl-2,2-difluoro-N-p-tolyl-acetamide 

Relevant articles and documents

METHOD FOR PREPARING DIFLUOROACETIC ACID ESTERS

A method for preparing difluoroacetic acid esters is described. The method can include reacting difluoroacetyl fluorine with an aliphatic or cycloaliphatic alcohol in the presence of a heterogeneous mineral base.

Preparation of compounds comprising a CHF2 or CHF group

Producing compounds (I) with a mono- or difluoromethyl group from compounds (II) with a mono- or difluorohalomethyl group, where halo is bromo, iodo or preferably chloro, comprises reacting (II) with zinc in the presence of an alcohol. An independent claim is also included for an azeotropic mixture of methyl difluoroacetate and methanol.

ALDOL REACTION OF IODODIFLUOROACETATE-Zn AND 2,2-DIFLUOROKETENE SILYL ACETAL

Generation of the Reformatsky reagent of difluoroacetate from the iodide(2) and the difluoroketene silyl acetal(3), and their aldol reaction are described.High anti-selectivity with chiral aldehyde (5d, 5f) was found in the case of the ketene silyl acetal(3b). 2,2-Difluoro-2-deoxy analogs of D-ribo- and L-galactopyranosides (1a, 1b) were effectively prepared.