(6-Bromopyridin-2-yl)methanol

Base Information

• Chemical Name: (6-Bromopyridin-2-yl)methanol
• CAS No.: 33674-96-3
• Molecular Formula: C6H6BrNO
• Molecular Weight: 188.024
• Hs Code.: 29333990
• European Community (EC) Number: 628-497-5
• DSSTox Substance ID: DTXSID10393238
• Nikkaji Number: J1.657.544E
• Wikidata: Q27454736
• Mol file: 33674-96-3.mol

Synonyms:33674-96-3;(6-bromopyridin-2-yl)methanol;2-Bromo-6-(hydroxymethyl)pyridine;2-Bromo-6-pyridinemethanol;2-BROMO-6-HYDROXYMETHYLPYRIDINE;(6-Bromo-Pyridin-2-yl)-Methanol;6-Bromo-2-(hydroxymethyl)pyridine;2-Pyridinemethanol, 6-bromo-;(6-Bromo-pyridin-2-yl)methanol;(6-bromo-pyridine-2-yl)methanol;6-Bromo-2-pyridinemethanol;6-bromopyridine-2-methanol;MFCD04039884;2-BROMOPYRIDINE-6-METHANOL;(6-bromo-2-pyridyl)methanol;6-bromopyridin-2-methanol;2-bromo-6-pyridine methanol;SCHEMBL105003;XDDGKNRSCDEWBR-UHFFFAOYA;6-bromo-2-hydroxymethylpyridine;(6-bromopyridine-2-yl)methanol;(6-Bromopyridin-2-yl)-methanol;DTXSID10393238;XDDGKNRSCDEWBR-UHFFFAOYSA-N;2-bromo-6-hydroxy methyl pyridine;CS-D0981;STR07119;AC-977;BBL100872;STL554666;AKOS005255305;FG-0513;PB29304;(6-Bromo-pyridin-2-yl)methanol, 96%;SY009306;AM20051087;B3736;FT-0639122;EN300-120028;A821904;J-400774;7-Amino-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide;Q27454736;InChI=1/C6H6BrNO/c7-6-3-1-2-5(4-9)8-6/h1-3,9H,4H2;4HU

Chemical Property of (6-Bromopyridin-2-yl)methanol

Chemical Property:

• Appearance/Colour: Pale yellow powder
• Vapor Pressure: 0.00107mmHg at 25°C
• Melting Point: 34-39 °C(lit.)
• Refractive Index: 1.598
• Boiling Point: 288.7 °C at 760 mmHg
• PKA: 13.09±0.10(Predicted)
• Flash Point: 128.4 °C
• PSA: 33.12000
• Density: 1.668 g/cm³
• LogP: 1.33640
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 186.96328
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

99% ^*data from raw suppliers

(6-Bromopyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)Br)CO
• Uses: 2-Bromo-6-pyridinemethanol is used in the preparation of 2,6-diaminopyridine compounds for treating diseases associated with amyloid or amyloid-like proteins, especially ocular diseases. It is an active pharmaceutical ingredient and an pharmaceutical adjuvant.

Technology Process of (6-Bromopyridin-2-yl)methanol

There total 20 articles about (6-Bromopyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → 2-bromo-6-(hydroxymethyl)pyridine (33674-96-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(00)01116-9

Reference yield: 98.0%

2,6-Dibromopyridine (626-05-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-6-(hydroxymethyl)pyridine (33674-96-3)

Guidance literature:

2,6-Dibromopyridine; N,N-dimethyl-formamide; With n-butyllithium;

With sodium tetrahydroborate;

DOI:10.1002/ejoc.200390214

Reference yield: 94.0%

2,5-dibromopyridine (624-28-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-bromo-6-(hydroxymethyl)pyridine (33674-96-3)

Guidance literature:

2,5-dibromopyridine; With n-butyllithium; In hexanes; toluene; at -78 ℃; for 2.33333h;

N,N-dimethyl-formamide; In hexanes; toluene; at -78 ℃;

upstream raw materials:

2,6-Dibromopyridine

N,N-dimethyl-formamide

6-bromo-pyridine-2-carboxylic acid

methyl 6-Bromopicolinate

Downstream raw materials:

6-bromo-2-pyridinecarbaldehyde

2-phenyl-6-(hydroxymethyl)-pyridine

2-hydroxymethyl-6-mesityl-pyridine

(6-bromo-1-oxypyridin-2-yl)methanol