tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

Base Information

Chemical Name:tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane
CAS No.:550998-34-0
Molecular Formula:C₂₃H₂₆BrClO₂Si
Molecular Weight:477.901
Hs Code.:

Synonyms:tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

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Chemical Property of tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

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Technology Process of tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

There total 8 articles about tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 550998-31-7
tert-butyl[(3,6-dibromo-8-chloro-2-naphthyl)oxy]dimethylsilane

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 550998-34-0
tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 3h; Heating;
DOI:10.1021/jm058173s

Reference yield:

: 550998-29-3
3,6-dibromo-8-chloro-2-naphthol

: 550998-34-0
tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / imidazole / dimethylformamide / 3 h

2: 69 percent / Pd[P(Ph)3]4 / tetrahydrofuran / 3 h / Heating

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm058173s

Reference yield:

: 29921-50-4
8-chloronaphthalen-2-ol

: 550998-34-0
tert-butyl[(3-bromo-8-chloro-6-(4-methoxyphenyl)-2-naphthyl)oxy]dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂; acetic acid / 1 h / 100 °C

2: 84 percent / imidazole / dimethylformamide / 3 h

3: 69 percent / Pd[P(Ph)3]4 / tetrahydrofuran / 3 h / Heating

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm058173s