N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester
CAS No.:1443793-15-4
Molecular Formula:C₅₃H₆₄N₃O₁₂P
Molecular Weight:966.078
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Suppliers and Price of N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

There total 11 articles about N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 75-91-2
tert.-butylhydroperoxide

: 1443793-02-9
N-tert-butyloxycarbonyl-D-[p-(benzyloxy)phenyl]glycine-L-serine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 1443793-15-4
N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Guidance literature:: N-tert-butyloxycarbonyl-D-[p-(benzyloxy)phenyl]glycine-L-serine-L-[p-(benzyloxy)phenyl]glycine benzyl ester; di-tert-butyl diisopropylphosphoramide; With 1H-tetrazole; In tetrahydrofuran; at 20 ℃; for 12h;

tert.-butylhydroperoxide; In tetrahydrofuran; decane; at 0 ℃; for 3h;
DOI:10.1021/jo4007893

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1443793-15-4
N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzene / 12 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 0.02 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.02 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: 1H-tetrazole / tetrahydrofuran / 12 h / 20 °C

5.2: 3 h / 0 °C

With 1H-tetrazole; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo4007893

Reference yield:

: 69489-40-3
D-2-[p-(benzyloxy)phenyl]glycine

: 1443793-15-4
N-(tert-butyloxycarbonyl)-D-[p-(benzyloxy)phenyl]glycine-L-tertbutylphosphoserine-L-[p-(benzyloxy)phenyl]glycine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 12 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.02 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: 1H-tetrazole / tetrahydrofuran / 12 h / 20 °C

3.2: 3 h / 0 °C

With 1H-tetrazole; (benzotriazol-1-yloxy)tripyrrolodinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jo4007893