(S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

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Chemical Name:(S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide
CAS No.:1561763-62-9
Molecular Formula:C₂₃H₁₆F₃N₃O₄
Molecular Weight:455.393
Hs Code.:

Synonyms:(S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

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Chemical Property of (S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

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Technology Process of (S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

There total 6 articles about (S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1561777-94-3
4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

: 98556-62-8
2-oxo-2,3-dihydro-1,3-benzoxazole-6-carbonitrile

: 1561763-62-9
(S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

Guidance literature:: With methanesulfonic acid; at 0 - 20 ℃; for 24h;

Reference yield:

: 405174-45-0
2-bromo-3-(but-3-en-1-yloxy)pyridine

: 1561763-62-9
(S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

2.2: 12 h / -78 - 20 °C

3.1: magnesium / tetrahydrofuran / 5 h

3.2: -78 °C

4.1: methanesulfonic acid / 24 h / 0 - 20 °C

With methanesulfonic acid; tetraethylammonium chloride; potassium acetate; palladium diacetate; sodium hydrogencarbonate; ozone; magnesium; triphenylphosphine; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; 3.1: |Grignard Reaction / 3.2: |Grignard Reaction / 4.1: |Ritter Amidation;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1561763-62-9
(S)-2-oxo-N-(4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)-2,3-dihydrobenzo[d]oxazole-6-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 17.5 h / 0 - 50 °C / Inert atmosphere

2.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

3.2: 12 h / -78 - 20 °C

4.1: magnesium / tetrahydrofuran / 5 h

4.2: -78 °C

5.1: methanesulfonic acid / 24 h / 0 - 20 °C

With methanesulfonic acid; tetraethylammonium chloride; potassium acetate; palladium diacetate; sodium hydrogencarbonate; ozone; magnesium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; 4.1: |Grignard Reaction / 4.2: |Grignard Reaction / 5.1: |Ritter Amidation;