4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

Base Information

Chemical Name:4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol
CAS No.:1561777-94-3
Molecular Formula:C₁₅H₁₂F₃NO₂
Molecular Weight:295.261
Hs Code.:

Synonyms:4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

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Chemical Property of 4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

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Technology Process of 4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

There total 4 articles about 4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 405174-48-3
2,3-dihydro-4H-pyrano[3,2-b]pyridine-4-one

: 1561777-94-3
4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

Guidance literature:: p-trifluoromethylphenyl bromide; With magnesium; In tetrahydrofuran; for 5h;

2,3-dihydro-4H-pyrano[3,2-b]pyridine-4-one; In tetrahydrofuran; at -78 ℃;

Reference yield:

: 405174-46-1
4-methylene-3,4-dihydro-2H-pyrano[3,2-b]pyridine

: 1561777-94-3
4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

1.2: 12 h / -78 - 20 °C

2.1: magnesium / tetrahydrofuran / 5 h

2.2: -78 °C

With sodium hydrogencarbonate; ozone; magnesium; In tetrahydrofuran; methanol; chloroform; 2.1: |Grignard Reaction / 2.2: |Grignard Reaction;

Reference yield:

: 405174-45-0
2-bromo-3-(but-3-en-1-yloxy)pyridine

: 1561777-94-3
4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; palladium diacetate; potassium acetate; tetraethylammonium chloride / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; ozone / methanol; chloroform / 16 h / -78 °C

2.2: 12 h / -78 - 20 °C

3.1: magnesium / tetrahydrofuran / 5 h

3.2: -78 °C

With tetraethylammonium chloride; potassium acetate; palladium diacetate; sodium hydrogencarbonate; ozone; magnesium; triphenylphosphine; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; 3.1: |Grignard Reaction / 3.2: |Grignard Reaction;