N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

Base Information

Chemical Name:N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide
CAS No.:1456614-59-7
Molecular Formula:C₁₆H₁₇N₅O₂S₂
Molecular Weight:375.475
Hs Code.:

Synonyms:N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

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Chemical Property of N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

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Technology Process of N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

There total 4 articles about N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1456614-47-3
N-(4-methyl-5-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

: 106-49-0,12221-03-3
p-toluidine

: 1456614-59-7
N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

Guidance literature:: In ethanol; for 3h; Reflux;
DOI:10.1016/j.ejmech.2013.06.029

Reference yield:

: 63788-64-7
2-acetamido-4-methylthiazole-5-carboxylic acid hydrazide

: 1456614-59-7
N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 12 h / Reflux

2: ethanol / 3 h / Reflux

With potassium hydroxide; In ethanol; 2: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.06.029

Reference yield:

: 2862-33-1
2-acetylamino-4-methylthiazole-5-carboxylic acid ethyl ester

: 1456614-59-7
N-(4-methyl-5-(5-thioxo-4-((p-tolylamino)methyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 5 h / Reflux

2: potassium hydroxide / ethanol / 12 h / Reflux

3: ethanol / 3 h / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol; 3: |Mannich Aminomethylation;
DOI:10.1016/j.ejmech.2013.06.029