2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole

Base Information

• Chemical Name: 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole
• CAS No.: 1370244-27-1
• Molecular Formula: C₁₉H₁₅ClN₂O₄S
• Molecular Weight: 402.858
• Mol file: 1370244-27-1.mol

Synonyms:2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole

Chemical Property of 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole

There total 5 articles about 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.6%

2-[3-chloro-4-(1-oxo-propyl)phenoxy]ethanethioamide (1370244-41-9) + 4-Nitrophenacyl bromide (99-81-0) → 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole (1370244-27-1)

Guidance literature:

In methanol; for 24h; Reflux;

DOI:10.1016/j.bmc.2012.02.011

Reference yield:

2-(3-chlorophenoxy)acetyl chloride (114476-84-5) → 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole (1370244-27-1)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / water; toluene / 1.5 h / 0 - 5 °C

2: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 50 °C

3: aluminum (III) chloride / carbon disulfide / 4.5 h / 20 - 50 °C

4: methanol / 24 h / Reflux

With aluminum (III) chloride; tetraphosphorus decasulfide; ammonia; In tetrahydrofuran; methanol; carbon disulfide; water; toluene; 3: Friedel-Crafts acylation;

DOI:10.1016/j.bmc.2012.02.011

Reference yield:

3-monochlorophenol (108-43-0) → 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole (1370244-27-1)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydroxide / 100 °C

2: thionyl chloride / 4 h / 80 °C

3: ammonia / water; toluene / 1.5 h / 0 - 5 °C

4: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 50 °C

5: aluminum (III) chloride / carbon disulfide / 4.5 h / 20 - 50 °C

6: methanol / 24 h / Reflux

With aluminum (III) chloride; thionyl chloride; tetraphosphorus decasulfide; ammonia; sodium hydroxide; In tetrahydrofuran; methanol; carbon disulfide; water; toluene; 5: Friedel-Crafts acylation;

DOI:10.1016/j.bmc.2012.02.011

upstream raw materials:

2-[3-chloro-4-(1-oxo-propyl)phenoxy]ethanethioamide

4-Nitrophenacyl bromide

3-monochlorophenol

2-(3-chlorophenoxy)acetyl chloride

Downstream raw materials:

2-(3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl)-4-(4-nitrophenyl)thiazole